Department of Psychiatry, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania.
Climacteric. 2013 Feb;16(1):185-93. doi: 10.3109/13697137.2012.682746. Epub 2012 Jul 31.
To assess sexual function in a clinical sample of Lithuanian postmenopausal women and identify the most important determinants of sexual function, including the use of hormone replacement therapy (HT), emotional status and menopausal symptoms.
Three hundred postmenopausal women who were referred to a gynecologist for a routine yearly check-up were enrolled for the study. Data for 246 women were appropriate for statistical analysis. Participants filled the Female Sexual Function Index for evaluation of sexual function, the Greene Climacteric Scale for the assessment of menopause symptoms and the Hospital Anxiety and Depression Scale for the evaluation of depression and anxiety symptoms.
Sexual function was better in younger women and in HT users compared with non-users. Thus, to analyze the other variables, an adjustment for age was applied. HT significantly increased the likelihood of higher desire, lubrication, satisfaction, and lower pain when adjusting results for age. HT reduced the likelihood of psychological and depression symptoms and increased the likelihood of vasomotor symptoms of menopause when results adjusted for age were analyzed. HT did not appear to affect anxiety symptoms after the results were adjusted for age.
HT increased chances for better sexual desire, lubrication, satisfaction, less pain and lower depression symptoms in postmenopausal women, even when the results were adjusted by age. HT did not improve sexual arousal, orgasm, menopausal and anxiety symptoms. Depression, anxiety, menopausal symptoms and age were the main risk factors for the possible development of sexual dysfunction.
评估立陶宛绝经后女性的临床样本中的性功能,并确定性功能的最重要决定因素,包括激素替代疗法(HRT)的使用、情绪状态和绝经症状。
招募了 300 名因常规年度体检而被转介给妇科医生的绝经后妇女参加本研究。有 246 名妇女的数据适合进行统计分析。参与者填写女性性功能指数以评估性功能,格林绝经量表评估绝经症状,医院焦虑和抑郁量表评估抑郁和焦虑症状。
与非使用者相比,年轻女性和 HRT 使用者的性功能更好。因此,为了分析其他变量,对年龄进行了调整。调整年龄后,HRT 显著增加了更高的欲望、润滑、满意度和较低的疼痛的可能性。调整年龄后的结果表明,HRT 降低了心理和抑郁症状的可能性,并增加了绝经期血管舒缩症状的可能性。HRT 似乎不会影响调整年龄后的焦虑症状。
即使在调整年龄后,HRT 也增加了绝经后女性更好的性欲、润滑、满意度、较少疼痛和较低抑郁症状的可能性。HRT 并未改善性唤起、性高潮、绝经和焦虑症状。抑郁、焦虑、绝经症状和年龄是性功能障碍发展的主要危险因素。