Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, Canada.
Nat Prod Res. 2013;27(12):1123-6. doi: 10.1080/14786419.2012.708662. Epub 2012 Jul 30.
Echeveria leucotricha J. A. Purpus (Crassulaceae) was evaluated for its potential antibacterial, antifungal, antiparasitic, cytotoxic and anti-inflammatory bioactivities. Aerial parts were extracted with hexane, methanol and chloroform, and fractionated accordingly. Biological activity was assessed in vitro against five Gram-positive and four Gram-negative bacteria, four human pathogenic fungi and the protozoan Leishmania donovani. Extracts and fractions showing bioactivities were further investigated for their cytotoxic activities on macrophages. Results show that several extracts and fractions exhibited significant antibacterial, antifungal, and antiparasitic activities, but no anti-inflammatory activity was recorded. Here, we report for the first time, and to the best of our knowledge, these bioactivities, which suggest that this plant can be used in the traditional Mexican medicine.
厚叶拟石莲花（景天科）的潜在抗菌、抗真菌、抗寄生虫、细胞毒性和抗炎生物活性进行了评估。用正己烷、甲醇和氯仿提取地上部分，并相应地进行馏分。在体外对 5 种革兰氏阳性菌和 4 种革兰氏阴性菌、4 种人体致病真菌和原生动物利什曼原虫进行了生物活性评估。对表现出生物活性的提取物和馏分进行了进一步的细胞毒性研究。结果表明，几种提取物和馏分表现出显著的抗菌、抗真菌和抗寄生虫活性，但没有抗炎活性。在这里，我们首次报告，据我们所知，这些生物活性表明，这种植物可以用于墨西哥传统医学。
