腺病毒载体和亚病毒颗粒用于蛋白质和肽类的递呈。
Adenovirus vectors and subviral particles for protein and peptide delivery.
机构信息
Department of Gene Therapy, University of Ulm, Helmholtzstr. 8/1, D-89081 Ulm, Germany.
出版信息
Curr Gene Ther. 2012 Oct;12(5):362-73. doi: 10.2174/156652312802762563.
PMID:22845888
Abstract
Adenovirus vectors belong to the most frequently used vector type in gene therapy approaches. In addition, adenovirus vector particles and adenovirus subviral particles offer a great potential for the direct delivery of proteins into cells. In this review we discuss this potential and the technology of adenovirus as a protein delivery platform for applications ranging from vaccination to gene therapy.
摘要
腺病毒载体属于基因治疗方法中最常使用的载体类型之一。此外，腺病毒载体颗粒和腺病毒亚病毒颗粒为将蛋白质直接递送到细胞中提供了巨大的潜力。在本综述中，我们讨论了这种潜力以及腺病毒作为蛋白质递送平台的技术，其应用范围从疫苗接种到基因治疗。
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