Fellows L E, Nash R J
Jodrell Laboratory, Royal Botanic Gardens, Kew.
Sci Prog. 1990;74(294 Pt 2):245-55.
A range of simple, natural chemicals almost unknown 20 years ago are now being used to advance research in cancer, AIDS, diabetes, immunology and plant-insect recognition. These alkaloids of the pyrrolidine, piperidine, pyrrolizidine and indolizidine classes resemble sugar molecules in the arrangement of hydroxyl substituents and are often potent and specific glycosidase inhibitors.
一系列在20年前还几乎无人知晓的简单天然化学物质，如今正被用于推动癌症、艾滋病、糖尿病、免疫学以及植物与昆虫识别方面的研究。这些吡咯烷、哌啶、吡咯里西啶和吲哚里西啶类生物碱在羟基取代基的排列上类似于糖分子，并且常常是强效且特异性的糖苷酶抑制剂。
