3B's Research Group-Biomaterials, Biodegradables & Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Taipas, Guimarães, Portugal.
Nanomedicine (Lond). 2012 Jul;7(7):1045-66. doi: 10.2217/nnm.12.78.
The field of biomaterials has advanced towards the molecular and nanoscale design of bioactive systems for tissue engineering, regenerative medicine and drug delivery. Spatial cues are displayed in the 3D extracellular matrix and can include signaling gradients, such as those observed during chemotaxis. Architectures range from the nanometer to the centimeter length scales as exemplified by extracellular matrix fibers, cells and macroscopic shapes. The main focus of this review is the application of a biomimetic approach by the combination of architectural cues, obtained through the application of micro- and nanofabrication techniques, with the ability to sequester and release growth factors and other bioactive agents in a spatiotemporal controlled manner for bone and cartilage engineering.
生物材料领域已经朝着生物活性系统的分子和纳米级设计方向发展，用于组织工程、再生医学和药物输送。空间线索显示在 3D 细胞外基质中，并且可以包括信号梯度，例如在趋化性过程中观察到的那些。结构从纳米到厘米长度范围不等，例如细胞外基质纤维、细胞和宏观形状。本篇综述的主要重点是通过结合微纳加工技术获得的结构线索，并通过在时空控制方式下隔离和释放生长因子和其他生物活性剂，应用仿生方法在骨和软骨工程中的应用。
