Lee Soo-Hong, Shin Heungsoo
Stem Cell Research Laboratory, CHA Stem Cell Institute, Pochon CHA University, Seoul, Republic of Korea.
Adv Drug Deliv Rev. 2007 May 30;59(4-5):339-59. doi: 10.1016/j.addr.2007.03.016. Epub 2007 Apr 12.
Regeneration of bone and cartilage defects can be accelerated by localized delivery of appropriate growth factors incorporated within biodegradable carriers. The carrier essentially allows the impregnated growth factor to release at a desirable rate and concentration, and to linger at injury sites for a sufficient time to recruit progenitors and stimulate tissue healing processes. In addition, the carrier can be formulated to have particular structure to facilitate cellular infiltration and growth. In this review, we present a summary of growth factor delivery carrier systems for bone and cartilage tissue engineering. Firstly, we describe a list of growth factors implicated in repair and regeneration of bone and cartilage by addressing their biological effects at different stages of the healing process. General requirements for localized growth factor delivery carriers are then discussed. We also provide selective examples of material types (natural and synthetic polymers, inorganic materials, and their composites) and fabricated forms of the carrier (porous scaffolds, microparticles, and hydrogels), highlighting the dose-dependent efficacy, release kinetics, animal models, and restored tissue types. Extensive discussion on issues involving currently investigated carriers for bone and cartilage tissue engineering approaches may illustrate future paths toward the development of an ideal growth factor delivery system.
通过将适当的生长因子包裹在可生物降解的载体中进行局部递送，可以加速骨和软骨缺损的再生。该载体本质上能使负载的生长因子以理想的速率和浓度释放，并在损伤部位停留足够长的时间以募集祖细胞并刺激组织愈合过程。此外，载体可以被设计成具有特定的结构以促进细胞浸润和生长。在这篇综述中，我们总结了用于骨和软骨组织工程的生长因子递送载体系统。首先，我们通过阐述它们在愈合过程不同阶段的生物学效应，列出了一系列与骨和软骨修复及再生相关的生长因子。然后讨论了局部生长因子递送载体的一般要求。我们还提供了材料类型（天然和合成聚合物、无机材料及其复合材料）和载体制成形式（多孔支架、微粒和水凝胶）的精选示例，重点介绍了剂量依赖性疗效、释放动力学、动物模型和修复的组织类型。对目前研究的用于骨和软骨组织工程方法的载体所涉及问题的广泛讨论，可能会阐明开发理想生长因子递送系统的未来路径。
