Munekage Eri, Takezaki Yuka, Hanazaki Kazuhiro
First Department of Surgery, Kochi Medical School, Kochi University, Japan.
Clin Calcium. 2012 Aug;22(8):1235-42.
It is reported that shortage of oral magnesium intake increase the incidence of diabetes. In addition, magnesium replacement therapy improves insulin resistance and glycemic control. Low levels of magnesium in the venous blood induce the disturbances of auto-phosphylation on the insulin receptor and deteriorate insulin resistance. Since magnesium is closely related to evolution and development of metabolic syndrome including diabetes mellitus and so on, magnesium is expected as potentially effective ingredient of drug therapy in the future perspectives.
据报道，口服镁摄入不足会增加糖尿病的发病率。此外，镁替代疗法可改善胰岛素抵抗和血糖控制。静脉血中镁含量低会导致胰岛素受体自身磷酸化紊乱，加重胰岛素抵抗。由于镁与包括糖尿病等在内的代谢综合征的发生发展密切相关，从未来前景看，镁有望成为药物治疗的潜在有效成分。
