Department of Obstetrics and Gynecology, S. João Hospital, Medical School, University of Porto, Porto, Portugal.
Fetal Diagn Ther. 2012;32(3):186-9. doi: 10.1159/000338113. Epub 2012 Jul 26.
To determine if in fetuses with aneuploidies the diameter of the fourth cerebral ventricle at 11-13 weeks' gestation is different from euploid fetuses.
The fourth ventricle at 11-13 weeks' gestation was assessed in 62 cases of trisomy 21, 32 of trisomy 18, 10 of trisomy 13, and 12 of triploidy and compared to 410 normal euploid fetuses. Transvaginal sonography was carried out and 3D brain volumes were acquired. The fetal head was assessed in an axial plane and the diameter of the fourth ventricle was measured. Values in aneuploid and euploid fetuses were compared.
The diameter of the fourth ventricle in trisomy 18, trisomy 13 and triploidy, but not in trisomy 21, was significantly higher than in euploid fetuses. In the euploid fetuses the median diameter of the fourth ventricle was 1.9 mm and the 95th percentile was 2.5 mm. The measurements were above the median and the 95th percentile in 25 (78.1%) and 17 (53.1%) cases of trisomy 18, in 10 (100%) and 8 (80.0%) of trisomy 13, and in 10 (83.3%) and 10 (83.3%) of triploidy.
In trisomy 18, trisomy 13 and triploidy the diameter of the fourth ventricle at 11-13 weeks' gestation is increased.
确定在 11-13 孕周的非整倍体胎儿中，第四脑室直径是否与整倍体胎儿不同。
在 62 例 21 三体、32 例 18 三体、10 例 13 三体和 12 例三倍体中评估 11-13 孕周的第四脑室，并与 410 例正常整倍体胎儿进行比较。经阴道超声检查获取 3D 脑容量。胎儿头部在轴位进行评估，测量第四脑室直径。比较非整倍体和整倍体胎儿的数值。
18 三体、13 三体和三倍体的第四脑室直径明显高于整倍体胎儿，但 21 三体除外。在整倍体胎儿中，第四脑室直径的中位数为 1.9mm，第 95 百分位数为 2.5mm。在 25 例（78.1%）18 三体和 17 例（53.1%）整倍体胎儿中，测量值高于中位数和第 95 百分位数，在 10 例（100%）13 三体和 8 例（80.0%）整倍体胎儿中，测量值高于中位数和第 95 百分位数，在 10 例（83.3%）三倍体和 10 例（83.3%）整倍体胎儿中，测量值高于中位数和第 95 百分位数。
在 18 三体、13 三体和三倍体中，11-13 孕周的第四脑室直径增加。
