Kuhn P, Brizot M L, Pandya P P, Snijders R J, Nicolaides K H
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, United Kingdom.
Am J Obstet Gynecol. 1995 Jan;172(1 Pt 1):32-5. doi: 10.1016/0002-9378(95)90080-2.
Our purpose was to investigate whether fetuses with aneuploidies demonstrate evidence of growth retardation during the first trimester.
This was a retrospective, cross-sectional study of singleton pregnancies undergoing fetal karyotyping at 10 to 13 weeks' gestation. Measurements of crown-rump length in 135 chromosomally abnormal fetuses were compared with those in 700 chromosomally normal fetuses.
The median crown-rump length of fetuses with trisomy 18 (n = 32) was significantly reduced. In contrast, in fetuses with trisomy 21 (n = 72), trisomy 13 (n = 11), 47,XXX (n = 6), 47,XXY (n = 6), 45,X (n = 5), and triploidy (n = 3) the crown-rump length was not lower than normal.
At 10 to 13 weeks' gestation fetuses with trisomy 18 are growth retarded, whereas in trisomy 21, trisomy 13, and sex chromosome aneuploidy growth is normal.
我们的目的是研究非整倍体胎儿在孕早期是否有生长迟缓的迹象。
这是一项对妊娠10至13周接受胎儿核型分析的单胎妊娠进行的回顾性横断面研究。将135例染色体异常胎儿的顶臀长度测量值与700例染色体正常胎儿的进行比较。
18三体胎儿（n = 32）的顶臀长度中位数显著降低。相比之下，21三体胎儿（n = 72）、13三体胎儿（n = 11）、47,XXX胎儿（n = 6）、47,XXY胎儿（n = 6）、45,X胎儿（n = 5）和三倍体胎儿（n = 3）的顶臀长度并不低于正常水平。
妊娠10至13周时，18三体胎儿生长迟缓，而21三体、13三体和性染色体非整倍体胎儿生长正常。
