Department of Neurology, Rouen University Hospital and University of Rouen, France.
J Neurol Sci. 2012 Oct 15;321(1-2):96-9. doi: 10.1016/j.jns.2012.07.033. Epub 2012 Jul 28.
Worsening of verbal fluency is reported after subthalamic nucleus deep brain stimulation in Parkinson's disease. It is postulated that these changes could reflect microlesion consecutive to the surgical procedure itself.
We evaluated verbal fluency, in 26 patients (mean age, 57.9±8.5 years; mean disease duration, 11.4±3.5 years) both before surgery (baseline) and, after surgery respectively the third day (T3), the tenth day (T10) just after STN implantation before turning on the stimulation and at six months (T180).
Number of total words and switches was significantly reduced at T3 and T10, while average cluster size was unchanged. Repeated post-operative neuropsychological testing demonstrated reliable improvement from T3 to T180 on verbal fluency.
This study provides evidence of transient verbal fluency decline consecutive to a microlesion effect. Further studies needed to determine a putative relationship between early and long-term verbal fluency impairment.
有报道称，在帕金森病患者的丘脑底核深部脑刺激后，言语流畅性会恶化。据推测，这些变化可能反映了手术本身引起的微小损伤。
我们评估了 26 名患者（平均年龄 57.9±8.5 岁；平均病程 11.4±3.5 年）的言语流畅性，分别在术前（基线）、术后第 3 天（T3）、第 10 天（T10），即在 STN 植入后开启刺激前，以及术后 6 个月（T180）进行。
T3 和 T10 时总词汇量和转换次数明显减少，而平均聚类大小不变。术后重复神经心理学测试显示，言语流畅性从 T3 到 T180 有可靠的改善。
本研究提供了术后微损伤导致言语流畅性短暂下降的证据。需要进一步研究以确定早期和长期言语流畅性损害之间的潜在关系。
