Division of Infectious Disease, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, Madison, WI, 53705, USA,
Curr Infect Dis Rep. 2012 Oct;14(5):558-65. doi: 10.1007/s11908-012-0285-1.
Septic arthritis of the native joint is an uncommon infection but, when present, creates a significant risk for functional impairment of the affected joint or, in severe cases, mortality. Knowledge of the most common pathogens, as well as appropriate diagnostics, can facilitate earlier diagnosis and treatment, which, ideally, leads to improved long-term outcomes. In this article, we discuss recent microbiologic trends and diagnostic tests, with an update on use of molecular testing. Empiric antibiotic regimens for native joint septic arthritis are reviewed, as well as potential new therapies on the horizon.
原发性关节感染性关节炎是一种罕见的感染，但如果发生，会显著增加受累关节功能障碍的风险，在严重的情况下，甚至会导致死亡。了解最常见的病原体以及适当的诊断方法可以促进早期诊断和治疗，从而理想地改善长期预后。在本文中，我们讨论了最近的微生物学趋势和诊断检测方法，并更新了分子检测的应用。还回顾了原发性关节感染性关节炎的经验性抗生素治疗方案，以及即将出现的潜在新疗法。
