Department of Physiology, University of Buenos Aires, MT Alvear 2142, 3rd. floor A, Buenos Aires, Argentina.
Bull Environ Contam Toxicol. 2012 Oct;89(4):693-8. doi: 10.1007/s00128-012-0753-1. Epub 2012 Jul 31.
Lead chronic intoxication under hypoxic conditions revealed growth retardation in growing rats and damages on femoral and mandibular bones that predispose to fractures. These findings aimed us to investigate if bone material and geometric properties, bone mass in terms of histomorphometry or antioxidant capacity are also impaired in such experimental model. Combined treatments significantly reduced hemimandible cross sectional geometry and intrinsic stiffness (-16% and -34%); tibia and hemimandible bone volume (-45% and -40%) and growth plate cartilage thickness (-19%). These results show a previously unreported toxic effect of lead on mandible however, longer studies should be necessary to evaluate if an adaptation of bone architecture to maintain structural properties may occur and if the oxidative stress can be identified as the primary contributory agent in the pathogenesis of lead poisoning.
在缺氧条件下导致的慢性铅中毒会使生长中的大鼠生长迟缓，并损害股骨和颌骨，从而容易导致骨折。这些发现促使我们研究在这种实验模型中，骨的物质和几何特性、组织形态计量学方面的骨量或抗氧化能力是否也受到损害。联合治疗显著降低了半下颌骨的横截面几何形状和固有刚度（分别降低了 16%和 34%）；胫骨和半下颌骨的体积（分别降低了 45%和 40%）以及生长板软骨的厚度（降低了 19%）。这些结果表明，铅对颌骨具有以前未报道过的毒性作用，然而，需要进行更长时间的研究，以评估骨骼结构是否会发生适应性改变以维持结构特性，以及氧化应激是否可以被确定为铅中毒发病机制中的主要促成因素。
