Department of Physiology, Faculty of Odontology, University of Buenos Aires, MT Alvear 2142, Buenos Aires, Argentina.
Bull Environ Contam Toxicol. 2012 Jun;88(6):1033-7. doi: 10.1007/s00128-012-0602-2. Epub 2012 Mar 29.
The existence of children living at high altitude suffering from lead (Pb) poisoning prompted us to investigate the long term effects of this pollutant on growth and bone biology in growing rats maintained at simulated high altitude (SHA). Pb and hypoxia (HX) significantly reduced body weight (-9.4 % and -24 %; p < 0.01) and length (-3 % and -8 %; p < 0.01); decreased femoral ultimate load (-16 % and -40 %; p < 0.01) and femoral energy absorption capacity (-18 % and -74 %; p < 0.01). Oral pathologic alterations were observed in experimental groups. Our findings revealed growth retardation and damages on femoral and mandibular bones that predispose to fractures.
儿童生活在高海拔地区且患有铅（Pb）中毒，这促使我们研究这种污染物对生长中的大鼠在模拟高海拔（SHA）环境下的生长和骨骼生物学的长期影响。铅和缺氧（HX）显著降低了体重（分别降低了 9.4%和 24%；p < 0.01）和长度（分别降低了 3%和 8%；p < 0.01）；降低了股骨的最大负荷（分别降低了 16%和 40%；p < 0.01）和股骨的能量吸收能力（分别降低了 18%和 74%；p < 0.01）。实验组出现了口腔病理改变。我们的研究结果表明，生长迟缓以及对股骨和下颌骨的损伤会导致骨折。
