一种可能的肝细胞癌进展预测标志物。
A possible predictive marker of progression for hepatocellular carcinoma.
作者信息
DI Stasio Michele, Volpe Maria Grazia, Colonna Giovanni, Nazzaro Melissa, Polimeno Miriam, Scala Stefania, Castello Giuseppe, Costantini Susan
机构信息
Institute of Food Sciences, CNR, Avellino.
出版信息
Oncol Lett. 2011 Nov;2(6):1247-1251. doi: 10.3892/ol.2011.378. Epub 2011 Aug 9.
Abstract
The correlation between decreased levels of selenium and increased DNA damage and oxidative stress shows the significance of this trace element. A number of studies have provided evidence for lower serum, plasma and tissue levels of selenium in patients with various diseases and types of cancer. In this study, liver selenium concentrations were measured in tissue samples of patients with hepatocellular carcinoma (HCC) by atomic absorption spectrometry. The results showed that the selenium concentrations decreased when the malignant grade increased. Furthermore, a significant correlation was found between selenium levels and human selenium binding protein-1 (SELENBP1) down-regulation in the liver. Therefore, we suggest that the evaluation of selenium and SELENBP1 concentrations can be used for improving the prognosis of HCC.
摘要
硒水平降低与DNA损伤增加及氧化应激之间的相关性表明了这种微量元素的重要性。多项研究已为患有各种疾病和癌症类型的患者血清、血浆及组织中硒水平较低提供了证据。在本研究中，通过原子吸收光谱法测量了肝细胞癌（HCC）患者组织样本中的肝脏硒浓度。结果显示，随着恶性程度增加，硒浓度降低。此外，还发现肝脏中硒水平与人类硒结合蛋白-1（SELENBP1）下调之间存在显著相关性。因此，我们建议评估硒和SELENBP1浓度可用于改善HCC的预后。
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