Zhang Ziwei, Bi Mingyu, Liu Qi, Yang Jie, Xu Shiwen
College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China.
Harbin Railway Public Security Bureau Police Dog Base, Harbin 150056, P. R. China.
Oncotarget. 2016 Nov 22;7(47):77110-77116. doi: 10.18632/oncotarget.12804.
Hepatocellular carcinoma (HCC) is the most common cancer type. There is a correlation between selenium (Se) deficiency and the incidence of HCC. To clarify the effects of Se level on the risk of HCC patients, a meta-analysis was performed. A total of 9 articles published between 1994 and 2016 worldwide were selected through searching PubMed, EMBASE, web of science, Cochrane Library, Springer Link, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM), and the information were analyzed using a meta-analysis method. Heterogeneity was assessed by using the I2 index. Publication bias was evaluated by Begg's Test analysis. Pooled analysis indicated that patients with HCC had lower Se levels than the healthy controls [standardized mean difference (SMD)= -1.08, 95% confidence intercal (CI) = (-0.136, -0.08), P < 0.001]. Further subgroup analysis showed this effect to be independent of the study design, race or sample collection. In conclusion, this meta-analysis suggested an inverse correlation between Se level and the risk of HCC in humans patients.
肝细胞癌（HCC）是最常见的癌症类型。硒（Se）缺乏与HCC的发病率之间存在关联。为了阐明硒水平对HCC患者风险的影响，进行了一项荟萃分析。通过检索PubMed、EMBASE、科学网、Cochrane图书馆、Springer Link、中国知网（CNKI）和中国生物医学数据库（CBM），共筛选出1994年至2016年间在全球发表的9篇文章，并采用荟萃分析方法对这些信息进行分析。使用I2指数评估异质性。通过Begg检验分析评估发表偏倚。汇总分析表明，HCC患者的硒水平低于健康对照组[标准化均值差（SMD）=-1.08，95%置信区间（CI）=（-0.136，-0.08），P<0.001]。进一步的亚组分析表明，这种效应与研究设计、种族或样本采集无关。总之，这项荟萃分析表明硒水平与人类HCC患者的风险呈负相关。
