尼泊尔一个药物警戒中心的药品不良反应报告
Adverse drug reaction reporting in a pharmacovigilance centre of Nepal.
作者信息
Jha N, Shankar P R, Bajracharya O, Gurung S B, Singh K K
机构信息
Department of Pharmacology, KIST Medical College, Lalitpur, Nepal.
出版信息
Australas Med J. 2012;5(5):268-71. doi: 10.4066/AMJ.2012.1142.. Epub 2012 May 31.
BACKGROUND
Pharmacovigilance is the "science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug related problems". Nepal joined the international pharmacovigilance programme as a full member in 2007. KIST Medical College, Lalitpur, Nepal joined the national programme as a regional centre from mid-July 2008. Currently, the pattern and scope of adverse drug reactions (ADRs) in Nepal remains unexplored.
AIMS
To observe and analyse the pattern of ADRs at KIST Medical College, Lalitpur, Nepal.
METHOD
A retrospective analysis of all ADRs reported to the centre from mid July 2008 to July 2011 was performed. Data was analysed for ADR severity, causality, and preventability.
RESULTS
A total of 113 ADR reports were obtained from various clinical departments. The maximum number of reactions was due to antimicrobials, followed by anti-hypertensives and NSAIDs.
CONCLUSION
Antimicrobials were the commonest group of drugs causing ADRs and the most commonly seen ADR was maculopapular rash followed by diarrhea and vomiting.
背景
药物警戒是“与药物不良反应或任何其他药物相关问题的发现、评估、理解和预防有关的科学与活动”。尼泊尔于2007年作为正式成员加入国际药物警戒计划。尼泊尔加德满都谷地的基斯特医学院于2008年7月中旬作为区域中心加入国家计划。目前，尼泊尔药物不良反应（ADR）的模式和范围仍未得到探索。
目的
观察和分析尼泊尔加德满都谷地基斯特医学院的药物不良反应模式。
方法
对2008年7月中旬至2011年7月期间向该中心报告的所有药物不良反应进行回顾性分析。分析了药物不良反应的严重程度、因果关系和可预防性数据。
结果
从各个临床科室共获得113份药物不良反应报告。反应最多的是抗菌药物，其次是抗高血压药物和非甾体抗炎药。
结论
抗菌药物是引起药物不良反应最常见的药物类别，最常见的药物不良反应是斑丘疹，其次是腹泻和呕吐。
Zotero 插件