Santosh K C, Tragulpiankit Pramote, Edwards I Ralph, Gorsanan Sarun
Faculty of Pharmacy, Department of Pharmacy, Mahidol University, Bangkok, Thailand.
Int J Risk Saf Med. 2013 Jan 1;25(1):1-16. doi: 10.3233/JRS-120578.
To investigate the knowledge about ADRs and ADR reporting among healthcare professionals working at four regional pharmacovigilance centers (RPCs) of Nepal.
It was a cross sectional study, done by a survey using a validated self-administered structured questionnaire. The questionnaire was distributed to 450 healthcare professionals working at four RPCs.
The overall response rate was 74%. Only 53% and 38% of respondents knew about the existence of National Pharmacovigilance Centre (NPC) and RPC, respectively. Among the respondents, 29% and 33% did not know what a Type A and Type B ADR was. Similarly, 30% and 45% were not aware of the common types of ADRs or the thalidomide tragedy. Only, 9% knew about Uppsala Monitoring Centre (UMC) and only 10% answered correctly about the Naranjo algorithm as a causality assessment tool for ADRs. Of the respondents, only 19% knew about spontaneous reporting system and only 18% were aware about its drawbacks. The overall mean score on knowledge about ADR among healthcare professionals was 7.64 ± 2.38 out of the maximum possible score of 12. Whereas, the overall mean score of knowledge about ADR reporting was 3.95 ± 1.78 out of maximum possible score of 11.
Healthcare professionals working at four RPCs of Nepal have some knowledge about ADRs themselves but limited knowledge about ADR reporting. There is an urgent need of action to be taken by RPCs at the regional level and NPC at the national level to improve knowledge and ADR reporting by healthcare professionals.
调查在尼泊尔四个地区药物警戒中心（RPC）工作的医疗保健专业人员对药品不良反应（ADR）及ADR报告的了解情况。
这是一项横断面研究，通过使用经过验证的自填式结构化问卷进行调查。问卷分发给在四个RPC工作的450名医疗保健专业人员。
总体回复率为74%。分别只有53%和38%的受访者知道国家药物警戒中心（NPC）和RPC的存在。在受访者中，分别有29%和33%不知道A型和B型ADR是什么。同样，30%和45%的人不知道ADR的常见类型或沙利度胺悲剧。只有9%的人知道乌普萨拉监测中心（UMC），只有10%的人正确回答了作为ADR因果关系评估工具的纳伦霍算法。在受访者中，只有19%的人知道自发报告系统，只有18%的人知道其缺点。医疗保健专业人员关于ADR知识的总体平均得分在满分12分中为7.64±2.38分。而关于ADR报告知识的总体平均得分在满分11分中为3.95±1.78分。
在尼泊尔四个RPC工作的医疗保健专业人员对ADR本身有一定了解，但对ADR报告的了解有限。地区层面的RPC和国家层面的NPC迫切需要采取行动，以提高医疗保健专业人员的知识水平和ADR报告率。
