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[苏联医学科学院谢马什克·弗拉基米罗维奇·阿尼奇科夫实验医学研究所药理学部神经药理学的研究成果与发展前景]

[Results and prospects of development of neuropharmacology in the department of pharmacology of the Acad. S. V. Anichkov Research Institute of Experimental Medicine, USSR Academy of Medical Sciences].

作者信息

Borodkin Iu S, Zavodskaia I S, Losev N A, Moreva E V, Sapronov N S

出版信息

Vestn Akad Med Nauk SSSR. 1990(11):16-23.

PMID:2284839
Abstract

Basic strategic and tactical principles of neuropharmacological studies are outlined, whose aim is to find and explore new synthetic neuro-blocking agents and substances simulating the structure of natural metabolites. The basic research has resulted in the development of new highly effective drugs and experimentally substantiated recommendations for their clinical application. The conceptions of the action mechanism of adrenergic and cholinergic agents, stimulants of tissue energy exchange, which have been formulated in the department, suggested new approaches to the pharmacological treatment of diseases of the central and peripheral nervous systems and neurogenic diseases of the gastrointestinal and cardiovascular systems.

摘要

概述了神经药理学研究的基本战略和战术原则,其目的是寻找和探索新的合成神经阻滞剂以及模拟天然代谢产物结构的物质。基础研究已促成了新型高效药物的研发,并为其临床应用提供了经实验证实的建议。该部门所阐述的肾上腺素能和胆碱能药物、组织能量交换刺激剂的作用机制概念,为中枢和外周神经系统疾病以及胃肠和心血管系统神经源性疾病的药物治疗提出了新方法。

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