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蕈样肉芽肿和卡波西肉瘤患者的临床实验研究

[A clinico-experimental study of patients with mycosis fungoides and Kaposi's sarcoma].

作者信息

Faradzhev Z G, Parfenova T M, Shevliagin V Ia, Bykovskiĭ A F

出版信息

Vestn Dermatol Venerol. 1990(9):11-4.

PMID:2284848
Abstract

Twenty-six cultures were prepared by the cultivation method. Continuous cells lines (IK-10 and IK-12) were obtained in two cases, in the rest short-lived cell cultures were prepared. All the isolated cell cultures were studied by transmission electron microscopy. Abnormal lymphoblasts were detected in some cell cultures isolated from the blood and lymph nodes of mycosis fungoides (IJ-137, IK-140, IK-142, IK-143) and Kaposi's sarcoma patients (IK-145). Cell population consisted of small, medium, and large lymphocytes. Electron microscopic examination has revealed retroviruses in IK-143 culture, isolated from the lymph node of a patient with mycosis fungoides. Morphologically these particles were typical of type C oncoviruses, 120-140 nm in diameter, with a spherical core in the center of the virion.

摘要

通过培养方法制备了26种培养物。在两例中获得了连续细胞系(IK - 10和IK - 12),其余的制备了短期存活的细胞培养物。所有分离的细胞培养物均通过透射电子显微镜进行研究。在从蕈样肉芽肿(IJ - 137、IK - 140、IK - 142、IK - 143)和卡波西肉瘤患者(IK - 145)的血液和淋巴结中分离出的一些细胞培养物中检测到异常淋巴母细胞。细胞群体由小淋巴细胞、中淋巴细胞和大淋巴细胞组成。电子显微镜检查在从一名蕈样肉芽肿患者淋巴结分离出的IK - 143培养物中发现了逆转录病毒。从形态学上看,这些颗粒是典型的C型肿瘤病毒,直径为120 - 140纳米,在病毒粒子中心有一个球形核心。

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