Carbone A, Volpe R, Laurent M, Di Filippo L
Bull Cancer. 1982;69(1):1-10.
A morphological analysis was carried out on a series of five patients, with tumor stage lesions of mycosis fungoides. The histological findings of skin, lymph nodes, spleen, liver and bone marrow were investigated. Histologically the cutaneous infiltrate consisted of large cells (mycosis cells) and small atypical lymphoid cells (Lutzner cells). Among the large cells, which predominated in number, two principal types of cell could be distinguished: lymphoid cells comparable to the Lutzner cells because of their nuclear configuration, and poorly differentiated basophilic and pyroninophilic cells with irregular nucleus ("reticulum" cells?) or regular nucleus ("T-immunoblasts"?). Ultrastructural data of cutaneous lesion obtained for study from only one patient, were consistent with these findings. Lesions of lymph nodes and viscera consisted of a cellular composition which closely resembled that of cutaneous lesions. In particular, the large so-called mycosis cells were always found and represented a supportive histologic feature in identifying this disease.
对一系列五名蕈样肉芽肿肿瘤分期病变患者进行了形态学分析。研究了皮肤、淋巴结、脾脏、肝脏和骨髓的组织学发现。组织学上，皮肤浸润由大细胞（蕈样细胞）和小的非典型淋巴细胞（吕茨纳细胞）组成。在数量上占主导的大细胞中，可以区分出两种主要类型的细胞：因其核形态与吕茨纳细胞相似的淋巴细胞，以及核不规则（“网状”细胞？）或规则（“T免疫母细胞”？）的低分化嗜碱性和嗜派洛宁性细胞。仅从一名患者获取用于研究的皮肤病变超微结构数据与这些发现一致。淋巴结和内脏病变的细胞组成与皮肤病变非常相似。特别是，总是能发现所谓 的大蕈样细胞，它们是识别这种疾病的一个支持性组织学特征。
