Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51542, Saudi Arabia.
Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah 51542, Saudi Arabia.
Int J Mol Sci. 2023 Jun 3;24(11):9719. doi: 10.3390/ijms24119719.
Cancer is one of the main causes of death in all developed and developing countries. Various factors are involved in cancer development and progression, including inflammation and alterations in cellular processes and signaling transduction pathways. Natural compounds have shown health-promoting effects through their antioxidant and anti-inflammatory potential, having an important role in the inhibition of cancer growth. In this regard, formononetin, a type of isoflavone, plays a significant role in disease management through the modulation of inflammation, angiogenesis, cell cycle, and apoptosis. Furthermore, its role in cancer management has been proven through the regulation of different signal transduction pathways, such as the signal transducer and activator of transcription 3 (STAT 3), Phosphatidyl inositol 3 kinase/protein kinase B (PI3K/Akt), and mitogen activating protein kinase (MAPK) signaling pathways. The anticancer potential of formononetin has been reported against various cancer types, such as breast, cervical, head and neck, colon, and ovarian cancers. This review focuses on the role of formononetin in different cancer types through the modulation of various cell signaling pathways. Moreover, synergistic effect with anticancer drugs and methods to improve bioavailability are explained. Thus, detailed studies based on clinical trials are required to explore the potential role of formononetin in cancer prevention and treatment.
癌症是所有发达国家和发展中国家的主要死亡原因之一。癌症的发生和发展涉及多种因素，包括炎症以及细胞过程和信号转导途径的改变。天然化合物通过其抗氧化和抗炎潜力显示出促进健康的作用，在抑制癌症生长方面发挥着重要作用。在这方面，芒柄花素作为一种异黄酮，通过调节炎症、血管生成、细胞周期和细胞凋亡，在疾病管理中发挥着重要作用。此外，其通过调节不同的信号转导途径，如信号转导和转录激活因子 3（STAT3）、磷脂酰肌醇 3 激酶/蛋白激酶 B（PI3K/Akt）和丝裂原激活蛋白激酶（MAPK）信号通路，在癌症管理中的作用已得到证实。芒柄花素已被报道具有抗癌潜力，可用于治疗多种癌症类型，如乳腺癌、宫颈癌、头颈部癌、结肠癌和卵巢癌。本综述重点介绍了芒柄花素通过调节不同细胞信号通路在不同癌症类型中的作用。此外，还解释了与抗癌药物的协同作用以及提高生物利用度的方法。因此，需要进行基于临床试验的详细研究来探索芒柄花素在癌症预防和治疗中的潜在作用。
