Department of Gastroenterology, Salford Royal NHS Foundation Trust, Salford, UK.
Rheumatology (Oxford). 2012 Oct;51(10):1747-56. doi: 10.1093/rheumatology/kes160. Epub 2012 Jul 31.
SSc is a chronic multi-system disease with wide-reaching consequences. Gastrointestinal features are present in over 90% of cases and these, together with other disease manifestations, may lead to nutritional decline. This produces substantial morbidity, including reliance on enteral support and even parenteral nutrition-dependent intestinal failure. These complications carry an associated mortality. Up to 18% of patients with SSc are reported to be at high risk of malnutrition [as assessed by Malnutrition Universal Screening Tool (MUST) criteria], with risk increasing with disease severity. Little is known about this decline, its rate of progression and how it affects the individual. Few case series report on nutritional interventions. Most current interventions are based on experience in other diseases. The development of specialist knowledge of SSc-related gastrointestinal disease management and nutritional screening and interventions is required. This paper reviews current knowledge relating to malnutrition and its management in SSc.
系统性硬化症是一种慢性多系统疾病，其后果广泛。超过 90%的病例存在胃肠道特征，这些特征与其他疾病表现一起可能导致营养下降。这会导致大量发病率，包括依赖肠内支持，甚至依赖肠外营养的肠道衰竭。这些并发症伴有相关死亡率。据报道，高达 18%的系统性硬化症患者存在营养不良的高风险[根据营养不良普遍筛查工具（MUST）标准评估]，且风险随疾病严重程度增加。对于这种下降、其进展速度以及如何影响个体，人们知之甚少。很少有病例系列报告营养干预措施。大多数当前的干预措施基于其他疾病的经验。需要制定与系统性硬化症相关胃肠道疾病管理和营养筛查及干预相关的专业知识。本文综述了与系统性硬化症相关的营养不良及其管理的现有知识。
