Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Rheum Dis Clin North Am. 2023 May;49(2):411-423. doi: 10.1016/j.rdc.2023.01.011.
Systemic sclerosis (SSc) is a rare multisystem autoimmune disease characterized by fibrosis, vasculopathy, and autoimmunity. Lesser known complications inherent to SSc, such as malignancies and osteoporosis, can lead to decreased quality of life and increased morbidity and mortality. Patients with SSc have a greater risk of developing malignancies than the general population. In addition, they are more likely to be vitamin D deficient and are at great risk of osteoporosis-related fractures. However, these complications can be addressed through preventative measures. The purpose of this review is to provide clinicians with an approach to bone health and cancer screening in SSc.
系统性硬化症（SSc）是一种罕见的多系统自身免疫性疾病，其特征为纤维化、血管病变和自身免疫。SSc 固有的不太为人知的并发症，如恶性肿瘤和骨质疏松症，可导致生活质量下降，发病率和死亡率增加。与普通人群相比，SSc 患者发生恶性肿瘤的风险更高。此外，他们更容易出现维生素 D 缺乏，并且存在与骨质疏松症相关的骨折的巨大风险。但是，可以通过预防措施来解决这些并发症。本文的目的是为临床医生提供 SSc 患者骨骼健康和癌症筛查的方法。
