双向同种异体反应性：一种基于微嵌合体的解决非我（NIMA）悖论的设想方案。
Bidirectional alloreactivity: A proposed microchimerism-based solution to the NIMA paradox.
作者信息
Burlingham William J, Benichou Gilles
机构信息
Department of Surgery, University of Wisconsin, Madison, WI, USA.
出版信息
Chimerism. 2012 Apr-Jun;3(2):29-36. doi: 10.4161/chim.21668. Epub 2012 Apr 1.
Abstract
The NIMA paradox is the observation that in transplants of allogeneic kidneys or hematopoietic stem cells, siblings benefit from re-exposure to non-inherited maternal antigens (NIMA), whereas re-exposure to a transplant from mother herself, theoretically the ideal "NIMA" donor, does not yield clinical results superior to a father-donated allograft. Recent observations of bidirectional alloreactivity in kidney and cord blood transplantation offer a possible solution to this paradox. If correct, the proposed solution points the way to clinical applications of microchimerism in solid organ and hematopoetic transplants.
摘要
NIMA 悖论是指在同种异体肾移植或造血干细胞移植中，同胞兄弟姐妹因再次接触非遗传的母体抗原（NIMA）而受益，然而，理论上理想的“NIMA”供体——母亲自身的移植，其临床效果并不优于父亲捐赠的同种异体移植物。最近在肾移植和脐血移植中双向同种异体反应性的观察结果为解决这一悖论提供了一种可能的方案。如果这一方案正确，那么它为微嵌合体在实体器官移植和造血移植中的临床应用指明了方向。
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