宫内造血干细胞移植（IUHCT）中的免疫学考量

Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT).

作者信息

Loewendorf Andrea I, Csete Marie, Flake Alan

机构信息

Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.

Chief Scientific Officer, The Huntington Medical Research Institutes Pasadena, CA, USA.

出版信息

Front Pharmacol. 2015 Jan 6;5:282. doi: 10.3389/fphar.2014.00282. eCollection 2014.

In utero hematopoietic stem cell transplantation (IUHCT) is an attractive approach and a potentially curative surgery for several congenital hematopoietic diseases. In practice, this application has succeeded only in the context of Severe Combined Immunodeficiency Disorders. Here, we review potential immunological hurdles for the long-term establishment of chimerism and discuss relevant models and findings from both postnatal hematopoietic stem cell transplantation and IUHCT.