宫内造血干细胞移植（IUHCT）中的免疫学考量
Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT).
作者信息
Loewendorf Andrea I, Csete Marie, Flake Alan
机构信息
Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.
Chief Scientific Officer, The Huntington Medical Research Institutes Pasadena, CA, USA.
出版信息
Front Pharmacol. 2015 Jan 6;5:282. doi: 10.3389/fphar.2014.00282. eCollection 2014.
In utero hematopoietic stem cell transplantation (IUHCT) is an attractive approach and a potentially curative surgery for several congenital hematopoietic diseases. In practice, this application has succeeded only in the context of Severe Combined Immunodeficiency Disorders. Here, we review potential immunological hurdles for the long-term establishment of chimerism and discuss relevant models and findings from both postnatal hematopoietic stem cell transplantation and IUHCT.
宫内造血干细胞移植（IUHCT）是一种有吸引力的方法，对于几种先天性造血疾病而言是一种潜在的治愈性手术。在实际应用中，这种方法仅在重症联合免疫缺陷疾病的背景下取得了成功。在此，我们回顾了嵌合体长期建立过程中潜在的免疫障碍，并讨论了来自出生后造血干细胞移植和宫内造血干细胞移植的相关模型及研究结果。
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