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宫内造血干细胞移植（IUHCT）中的免疫学考量

Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT).

作者信息

Loewendorf Andrea I, Csete Marie, Flake Alan

机构信息

Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.

Chief Scientific Officer, The Huntington Medical Research Institutes Pasadena, CA, USA.

出版信息

Front Pharmacol. 2015 Jan 6;5:282. doi: 10.3389/fphar.2014.00282. eCollection 2014.

DOI:10.3389/fphar.2014.00282
PMID:25610396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4285014/
Abstract

In utero hematopoietic stem cell transplantation (IUHCT) is an attractive approach and a potentially curative surgery for several congenital hematopoietic diseases. In practice, this application has succeeded only in the context of Severe Combined Immunodeficiency Disorders. Here, we review potential immunological hurdles for the long-term establishment of chimerism and discuss relevant models and findings from both postnatal hematopoietic stem cell transplantation and IUHCT.

摘要

宫内造血干细胞移植（IUHCT）是一种有吸引力的方法，对于几种先天性造血疾病而言是一种潜在的治愈性手术。在实际应用中，这种方法仅在重症联合免疫缺陷疾病的背景下取得了成功。在此，我们回顾了嵌合体长期建立过程中潜在的免疫障碍，并讨论了来自出生后造血干细胞移植和宫内造血干细胞移植的相关模型及研究结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9628/4285014/f8fa77d86556/fphar-05-00282-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9628/4285014/7dfc33696c0f/fphar-05-00282-g0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9628/4285014/009098eb5587/fphar-05-00282-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9628/4285014/ba9998a1ed10/fphar-05-00282-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9628/4285014/f8fa77d86556/fphar-05-00282-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9628/4285014/7dfc33696c0f/fphar-05-00282-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9628/4285014/1a33d856eec4/fphar-05-00282-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9628/4285014/009098eb5587/fphar-05-00282-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9628/4285014/ba9998a1ed10/fphar-05-00282-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9628/4285014/f8fa77d86556/fphar-05-00282-g0005.jpg

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Regulatory T cells promote alloengraftment in a model of late-gestation in utero hematopoietic cell transplantation.

本文引用的文献

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Necroptotic signaling in adaptive and innate immunity.适应性免疫和固有免疫中的坏死性凋亡信号传导
Semin Cell Dev Biol. 2014 Nov;35:33-9. doi: 10.1016/j.semcdb.2014.07.003. Epub 2014 Jul 18.
2
Stable long-term mixed chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation.在同种异体宫内造血细胞移植的犬模型中实现了稳定的长期混合嵌合体。
Blood. 2014 Sep 18;124(12):1987-95. doi: 10.1182/blood-2013-11-537571. Epub 2014 May 28.
3
Maternal-fetal cellular trafficking: clinical implications and consequences.
调节性T细胞在妊娠晚期子宫内造血细胞移植模型中促进同种异体移植物植入。
Blood Adv. 2020 Mar 24;4(6):1102-1114. doi: 10.1182/bloodadvances.2019001208.
4
In Utero Transplantation of Expanded Autologous Amniotic Fluid Stem Cells Results in Long-Term Hematopoietic Engraftment.子宫内输注扩增的自体羊水干细胞可实现长期造血嵌合。
Stem Cells. 2019 Sep;37(9):1176-1188. doi: 10.1002/stem.3039. Epub 2019 Jul 29.
5
Ultrasound-guided in Utero Transplantation of Placental Stem Cells into the Liver of Crigler-Najjar Syndrome Model Rat.超声引导下胎盘干细胞经子宫内移植入肝豆状核变性模型大鼠肝脏。
Transplantation. 2019 Jul;103(7):e182-e187. doi: 10.1097/TP.0000000000002735.
6
Pre-Existing Maternal Antibodies Cause Rapid Prenatal Rejection of Allotransplants in the Mouse Model of In Utero Hematopoietic Cell Transplantation.预先存在的母体抗体导致在体内造血细胞移植的小鼠模型中同种异体移植物的快速产前排斥。
J Immunol. 2018 Sep 1;201(5):1549-1557. doi: 10.4049/jimmunol.1800183. Epub 2018 Jul 18.
母胎细胞转运：临床意义及后果
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Development of the hematopoietic system and disorders of hematopoiesis that present during infancy and early childhood.造血系统的发育和婴儿及幼儿期出现的造血功能紊乱。
Pediatr Clin North Am. 2013 Dec;60(6):1273-89. doi: 10.1016/j.pcl.2013.08.002.
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Am J Reprod Immunol. 2013 Apr;69(4):346-58. doi: 10.1111/aji.12083. Epub 2013 Feb 25.