荧光染料对恶性疟原虫无性血期的体外活性。
In vitro activity of fluorescent dyes against asexual blood stages of Plasmodium falciparum.
机构信息
Institut für Tropenmedizin, Eberhard Karls Universität, Tübingen, Germany.
出版信息
Antimicrob Agents Chemother. 2012 Nov;56(11):5982-5. doi: 10.1128/AAC.00709-12. Epub 2012 Jul 30.
Abstract
Many successful antimicrobial drugs originate from synthetic dyes. This paper reports the in vitro activity of 14 fluorescent dyes against Plasmodium falciparum. Five of these dyes (Hoechst 33342, MitoRed, DiOC(6), SYTO 9, and rhodamine B) show activity at a low nanomolar concentration against two P. falciparum strains in the histidine-rich protein 2 drug sensitivity assay, while toxicity in HeLa cells is low. These dyes may be a starting point for developing new drugs against P. falciparum.
摘要
许多成功的抗菌药物来源于合成染料。本文报道了 14 种荧光染料对恶性疟原虫的体外活性。这 5 种染料（Hoechst 33342、MitoRed、DiOC(6)、SYTO 9 和罗丹明 B）在组氨酸丰富蛋白 2 药物敏感性测定中对两种恶性疟原虫株显示出低纳摩尔浓度的活性，而对 HeLa 细胞的毒性较低。这些染料可能是开发针对恶性疟原虫的新药的起点。
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