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Pasireotide.

作者信息

Feelders Richard A, Yasothan Uma, Kirkpatrick Peter

出版信息

Nat Rev Drug Discov. 2012 Aug;11(8):597-8. doi: 10.1038/nrd3788.

DOI:10.1038/nrd3788
PMID:22850776
Abstract
摘要

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Pasireotide Exerts Anti-Inflammatory Effects in the Endothelium.帕西瑞肽在内皮细胞中发挥抗炎作用。
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Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome.米非司酮,一种糖皮质激素受体拮抗剂,可给库欣综合征患者带来临床和代谢获益。
J Clin Endocrinol Metab. 2012 Jun;97(6):2039-49. doi: 10.1210/jc.2011-3350. Epub 2012 Mar 30.
2
A 12-month phase 3 study of pasireotide in Cushing's disease.一项为期 12 个月的培塞利肽治疗库欣病的 3 期研究。
N Engl J Med. 2012 Mar 8;366(10):914-24. doi: 10.1056/NEJMoa1105743.
3
Pasireotide alone or with cabergoline and ketoconazole in Cushing's disease.
Acta Pharmacol Sin. 2024 Nov;45(11):2432-2440. doi: 10.1038/s41401-024-01314-8. Epub 2024 Jun 26.
4
Instability Challenges and Stabilization Strategies of Pharmaceutical Proteins.药用蛋白质的稳定性挑战与稳定化策略
Pharmaceutics. 2022 Nov 20;14(11):2533. doi: 10.3390/pharmaceutics14112533.
5
Pasireotide for Refractory Hypoglycemia in Malignant Insulinoma- Case Report and Review of the Literature.生长抑素类似物帕瑞肽治疗恶性胰岛素瘤难治性低血糖症:病例报告及文献复习。
Front Endocrinol (Lausanne). 2022 Apr 19;13:860614. doi: 10.3389/fendo.2022.860614. eCollection 2022.
6
Overview of Radiolabeled Somatostatin Analogs for Cancer Imaging and Therapy.放射性标记生长抑素类似物在癌症成像和治疗中的概述。
Molecules. 2020 Sep 2;25(17):4012. doi: 10.3390/molecules25174012.
7
Evaluation of Pan-SSTRs Targeted Radioligand [Cu]NOTA-PA1 Using Micro-PET Imaging in Xenografted Mice.使用微型PET成像在异种移植小鼠中评估泛生长抑素受体(Pan-SSTRs)靶向放射性配体[铜]NOTA-PA1
ACS Med Chem Lett. 2020 Feb 12;11(4):445-450. doi: 10.1021/acsmedchemlett.9b00544. eCollection 2020 Apr 9.
8
The medical treatment with pasireotide in Cushing's disease: an Italian multicentre experience based on "real-world evidence".帕瑞肽在库欣病治疗中的应用:基于“真实世界证据”的意大利多中心经验。
Endocrine. 2019 Jun;64(3):657-672. doi: 10.1007/s12020-018-1818-7. Epub 2019 Apr 9.
9
G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?G 蛋白偶联受体作为已批准药物的靶点:有多少个靶点和多少种药物?
Mol Pharmacol. 2018 Apr;93(4):251-258. doi: 10.1124/mol.117.111062. Epub 2018 Jan 3.
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SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile.SOM230:一种新型生长抑素肽模拟物,具有广泛的生长激素释放抑制因子(SRIF)受体结合能力及独特的抗分泌特性。
Eur J Endocrinol. 2002 May;146(5):707-16. doi: 10.1530/eje.0.1460707.