Ma Li-li, Zeng Xiao-qing, Lian Jing-jing, Chen Jie, Li Quan-lin, Chen Shi-yao
Fudan University, Shanghai, Chnia.
Zhonghua Wei Chang Wai Ke Za Zhi. 2012 Jul;15(7):691-3.
To evaluate the long-term efficacy and safety of endoscopic tissue adhesive(N-octyl-α-cyanoacrylate) injection for the treatment of gastric varices.
A retrospective study was performed to review the clinical and follow up data of 169 patients with gastric variceal who received tissue adhesive injection at the Fudan University Affiliated Zhongshan Hospital between April 2004 and December 2011.
There were 128 males and 41 females with a mean age of 56.8(37-85) years old. One hundred and thirty-one patients received one injection, 38 received two injections or more with a mean of 1.12 per patient. Volume of injection ranged from 1 to 3 ml(mean, 1.7 ml). Eighty-three patients received adhesive injection alone, 231 received injection combined with ligation, 50 received combined sclerotic agent injection. All the patients had follow up ranging from 1 to 78 months(mean, 3.4 months). The treatment outcome was satisfactory in 130 patients(76.9%), good in 36(21.3%), and ineffective in 3(1.8%). The rate of ectopic embolization was 3.0%, and the rate of early re-bleeding was 1.2%. Postoperatively there were no septic complications or esophageal stricture. There were no deaths within 2 weeks.
Injection of tissue adhesive under endoscopic guidance for treatment of gastric varices is convenient, safe and effective.
评估内镜下注射组织黏合剂（N-辛基-α-氰基丙烯酸酯）治疗胃静脉曲张的长期疗效及安全性。
进行一项回顾性研究，以回顾2004年4月至2011年12月期间在复旦大学附属中山医院接受组织黏合剂注射治疗的169例胃静脉曲张患者的临床及随访资料。
男性128例，女性41例，平均年龄56.8（37 - 85）岁。131例患者接受一次注射，38例接受两次或更多次注射，平均每人1.12次。注射量为1至3毫升（平均1.7毫升）。83例患者单独接受黏合剂注射，231例接受注射联合结扎，50例接受联合硬化剂注射。所有患者随访1至78个月（平均3.4个月）。治疗效果满意者130例（76.9%），良好者36例（21.3%），无效者3例（1.8%）。异位栓塞率为3.0%，早期再出血率为1.2%。术后无感染并发症或食管狭窄。2周内无死亡病例。
内镜引导下注射组织黏合剂治疗胃静脉曲张方便、安全且有效。
