Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, Korea.
Inflamm Res. 2012 Dec;61(12):1355-62. doi: 10.1007/s00011-012-0536-5. Epub 2012 Aug 1.
The aim of this study was to determine whether the ADAM33 (a disintegrin and metalloproteinase domain 33) T1 (rs2280091), T2 (rs2280090), and ST+7 (rs574174) polymorphisms confer susceptibility to asthma.
A meta-analysis stratified by ethnicity and age was conducted on associations between the ADAM33 T1, T2, and ST+7 polymorphisms and asthma.
Eleven studies, which included 4,124 patients and 7,094 controls, were available for the meta-analysis. Meta-analysis revealed an association between asthma and the ADAM33 T1 GG genotype [odds ratio (OR) = 2.257, 95 % confidence interval (CI) = 1.577-3.228, p = 8.42 × 10(-7)]. Stratification by ethnicity indicated an association between this genotype and asthma in Asians (OR = 2.683, 95 % CI = 1.799-4.001, p = 1.31 × 10(-7)), and stratification by age indicated an association between it and asthma in adults (OR = 1.895, 95 % CI = 1.005-3.573, p = 0.048). However, no association was found between asthma and the ADAM33 T2 and ST+7 polymorphisms.
This meta-analysis demonstrates that the ADAM33 T1 polymorphism confers susceptibility to asthma in Asians, but no association was found between the ADAM33 T2 and ST+7 polymorphisms and asthma susceptibility.
本研究旨在确定解整合素金属蛋白酶域 33（ADAM33）T1（rs2280091）、T2（rs2280090）和 ST+7（rs574174）多态性是否与哮喘易感性相关。
根据种族和年龄对 ADAM33 T1、T2 和 ST+7 多态性与哮喘之间的关联进行了荟萃分析。
共有 11 项研究，包括 4124 例患者和 7094 例对照，可用于荟萃分析。荟萃分析显示，ADAM33 T1 GG 基因型与哮喘之间存在关联[比值比（OR）=2.257，95%置信区间（CI）=1.577-3.228，p=8.42×10(-7)]。按种族分层显示，该基因型与亚洲人群哮喘之间存在关联（OR=2.683，95%CI=1.799-4.001，p=1.31×10(-7))，按年龄分层显示，该基因型与成年人哮喘之间存在关联（OR=1.895，95%CI=1.005-3.573，p=0.048）。然而，ADAM33 T2 和 ST+7 多态性与哮喘之间没有关联。
本荟萃分析表明，ADAM33 T1 多态性使亚洲人群易患哮喘，但 ADAM33 T2 和 ST+7 多态性与哮喘易感性之间没有关联。
