骶神经调节治疗难治性膀胱过度活动症：一个古老问题的新兴工具。
Sacral neuromodulation and refractory overactive bladder: an emerging tool for an old problem.
机构信息
Department of Urology, King Abdulaziz University Hospital, P.O. Box 80215, Jeddah, 21589 Kingdom of Saudi Arabia.
出版信息
Ther Adv Urol. 2012 Aug;4(4):179-85. doi: 10.1177/1756287212445179.
Abstract
Overactive bladder (OAB) syndrome negatively affects the daily life of many people. Conservative treatments, such as antimuscarinics, do not always lead to sufficient improvement of the complaints and are often associated with considerable side effects resulting in treatment failure. In the case of failure or intolerable side effects, sacral neuromodulation (SNM) and botulinum toxin intravesical injections are minimally invasive and reversible alternatives. Currently, both SNM and botulinum toxin injection have FDA approval for use in OAB patients. This mini-review attempts to provide an update on SNM as a second-line management of adults with refractory OAB, based on the available clinical evidence concerning the efficacy and safety.
摘要
膀胱过度活动症（OAB）综合征会对许多人的日常生活造成负面影响。保守治疗，如抗毒蕈碱药物，并不总是能使症状得到充分改善，而且常常伴有相当大的副作用，导致治疗失败。在治疗失败或无法耐受副作用的情况下，骶神经调节（SNM）和膀胱内注射肉毒毒素是微创且可逆转的替代方法。目前，SNM 和膀胱内注射肉毒毒素均获得 FDA 批准用于 OAB 患者。本迷你综述基于有关疗效和安全性的现有临床证据，尝试就 SNM 作为难治性 OAB 成人二线治疗方法提供最新信息。
相似文献
1
Sacral neuromodulation and refractory overactive bladder: an emerging tool for an old problem.骶神经调节治疗难治性膀胱过度活动症：一个古老问题的新兴工具。
Ther Adv Urol. 2012 Aug;4(4):179-85. doi: 10.1177/1756287212445179.
2
Current information on sacral neuromodulation and botulinum toxin treatment for refractory idiopathic overactive bladder syndrome: a review.骶神经调节和肉毒杆菌毒素治疗难治性特发性膀胱过度活动症的最新信息：综述
Urol Int. 2010;84(3):245-53. doi: 10.1159/000288223. Epub 2010 Apr 13.
3
[Update on the second line management of idiopathic overactive bladder].[特发性膀胱过度活动症二线治疗的最新进展]
Prog Urol. 2009 Sep;19(8):530-7. doi: 10.1016/j.purol.2009.02.001. Epub 2009 Mar 19.
4
A comparative study between sacral neuromodulation and intravesical botulinum toxin injection for patients with refractory overactive bladder.难治性膀胱过度活动症患者骶神经调节与膀胱内注射肉毒杆菌毒素的比较研究
Arab J Urol. 2020 Mar 23;18(2):88-93. doi: 10.1080/2090598X.2020.1740391.
5
Botulinum toxin injections for adults with overactive bladder syndrome.肉毒杆菌毒素注射治疗成人膀胱过度活动症
Cochrane Database Syst Rev. 2011 Dec 7(12):CD005493. doi: 10.1002/14651858.CD005493.pub3.
6
Sacral neuromodulation in patients with refractory overactive bladder symptoms after failed Botulinum toxin therapy: Results in a large cohort of patients.经肉毒杆菌毒素治疗失败的难治性过度活动膀胱症状患者的骶神经调节：一项大型患者队列研究结果。
Neurourol Urodyn. 2021 Jun;40(5):1120-1125. doi: 10.1002/nau.24670. Epub 2021 Apr 8.
7
Overactive bladder syndrome: Current pathophysiological concepts and therapeutic approaches.膀胱过度活动症：当前的病理生理概念与治疗方法
Arab J Urol. 2013 Dec;11(4):313-8. doi: 10.1016/j.aju.2013.07.006. Epub 2013 Sep 18.
8
Sacral neuromodulation for refractory overactive bladder after prior intravesical onabotulinumtoxinA treatment.骶神经调节用于先前膀胱内注射A型肉毒毒素治疗后难治性膀胱过度活动症
Neurourol Urodyn. 2017 Jun;36(5):1377-1381. doi: 10.1002/nau.23117. Epub 2016 Sep 9.
9
Sacral neuromodulation and intravesical botulinum toxin for refractory overactive bladder.骶神经调节和膀胱内肉毒毒素治疗难治性膀胱过度活动症。
Curr Opin Obstet Gynecol. 2012 Oct;24(5):331-6. doi: 10.1097/GCO.0b013e3283573ff9.
10
[Second-line therapy of idiopathic detrusor overactivity. Sacral neuromodulation and botulinum toxin A].[特发性逼尿肌过度活动的二线治疗。骶神经调节和肉毒杆菌毒素A]
Urologe A. 2010 Feb;49(2):245-52. doi: 10.1007/s00120-009-2139-5.
引用本文的文献
1
Precise control of tibial nerve stimulation for bladder regulation via evoked compound action potential feedback mechanisms.通过诱发复合动作电位反馈机制精确控制胫神经刺激以调节膀胱功能。
Nat Commun. 2025 May 2;16(1):4115. doi: 10.1038/s41467-025-59436-4.
2
Sacral neuromodulation for neurological disease-induced lower urinary tract symptoms in Saudi Arabia: a single-centre experience.沙特阿拉伯神经源性下尿路症状的骶神经调节：单中心经验。
J Int Med Res. 2022 Aug;50(8):3000605221117221. doi: 10.1177/03000605221117221.
3
Sacral Neuromodulation for Lower Urinary Tract Symptoms: Effect of Therapy on Saudi Patient Sexual Function.骶神经调节治疗下尿路症状：该疗法对沙特患者性功能的影响。
Sex Med. 2021 Aug;9(4):100388. doi: 10.1016/j.esxm.2021.100388. Epub 2021 Jul 15.
4
Comparing the Efficacy of OnabotulinumtoxinA, Sacral Neuromodulation, and Peripheral Tibial Nerve Stimulation as Third Line Treatment for the Management of Overactive Bladder Symptoms in Adults: Systematic Review and Network Meta-Analysis.比较肉毒杆菌毒素 A、骶神经调节和外周胫骨神经刺激作为成人治疗过度活跃膀胱症状的三线治疗方法的疗效：系统评价和网络荟萃分析。
Toxins (Basel). 2020 Feb 18;12(2):128. doi: 10.3390/toxins12020128.
5
Percutaneous Nerve Evaluation Test Versus Staged Test Trials for Sacral Neuromodulation: Sensitivity, Specificity, and Predictive Values of Each Technique.经皮神经评估测试与骶神经调节的分期测试试验：每种技术的敏感性、特异性和预测价值。
Int Neurourol J. 2016 Sep;20(3):250-254. doi: 10.5213/inj.1630498.249. Epub 2016 Sep 23.
6
Effect of sacral neuromodulation on female sexual function and quality of life: Are they correlated?骶神经调节对女性性功能和生活质量的影响：它们相关吗？
Can Urol Assoc J. 2014 Nov;8(11-12):E762-7. doi: 10.5489/cuaj.2300.
本文引用的文献
1
Principles of Sacral Nerve Stimulation (SNS) for the Treatment of Bladder and Urethral Sphincter Dysfunctions.骶神经刺激（SNS）治疗膀胱和尿道括约肌功能障碍的原则。
Neuromodulation. 2000 Jan;3(1):16-26. doi: 10.1046/j.1525-1403.2000.00015.x.
2
Pelvic electrical neuromodulation for the treatment of overactive bladder symptoms.盆腔电神经调节治疗膀胱过度活动症症状。
Adv Urol. 2011;2011:757454. doi: 10.1155/2011/757454. Epub 2011 May 14.
3
Results of sacral neuromodulation therapy for urinary voiding dysfunction: outcomes of a prospective, worldwide clinical study.骶神经调节疗法治疗排尿功能障碍的结果：一项前瞻性全球临床研究的成果
J Urol. 2007 Nov;178(5):2029-34. doi: 10.1016/j.juro.2007.07.032. Epub 2007 Sep 17.
4
Bladder inhibition or voiding induced by pudendal nerve stimulation in chronic spinal cord injured cats.慢性脊髓损伤猫中阴部神经刺激引起的膀胱抑制或排尿
Neurourol Urodyn. 2007;26(4):570-577. doi: 10.1002/nau.20374.
5
Predicting implantation with a neuromodulator using two different test stimulation techniques: A prospective randomized study in urge incontinent women.使用两种不同的测试刺激技术，通过神经调节剂预测植入情况：一项针对急迫性尿失禁女性的前瞻性随机研究。
Neurourol Urodyn. 2007;26(1):14-8. doi: 10.1002/nau.20332.
6
Sacral neuromodulation for refractory lower urinary tract dysfunction: results of a nationwide registry in Switzerland.骶神经调节治疗难治性下尿路功能障碍：瑞士全国性登记研究结果
Eur Urol. 2007 May;51(5):1357-63. doi: 10.1016/j.eururo.2006.11.011. Epub 2006 Nov 13.
7
Sacral nerve stimulation for voiding dysfunction: One institution's 11-year experience.骶神经刺激治疗排尿功能障碍：一家机构的11年经验。
Neurourol Urodyn. 2007;26(1):19-28; discussion 36. doi: 10.1002/nau.20345.
8
Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study.五个国家基于人群的尿失禁、膀胱过度活动症及其他下尿路症状调查：EPIC研究结果
Eur Urol. 2006 Dec;50(6):1306-14; discussion 1314-5. doi: 10.1016/j.eururo.2006.09.019. Epub 2006 Oct 2.
9
In patients undergoing neuromodulation for intractable urge incontinence a reduction in 24-hr pad weight after the initial test stimulation best predicts long-term patient satisfaction.在接受神经调节治疗顽固性急迫性尿失禁的患者中，初始测试刺激后24小时尿垫重量的减轻最能预测患者的长期满意度。
Neurourol Urodyn. 2007;26(2):213-7. doi: 10.1002/nau.20330.
10
Complications and troubleshooting of two-stage sacral neuromodulation therapy: a single-institution experience.两阶段骶神经调节治疗的并发症及故障排除：单机构经验
Urology. 2006 Sep;68(3):533-7. doi: 10.1016/j.urology.2006.03.020. Epub 2006 Sep 18.
Zotero 插件