Shankar Anoop, Teppala Srinivas, Sabanayagam Charumathi
Department of Community Medicine, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, 1 Medical Center Drive, P.O. Box 9190, Morgantown, WV 26505-9190, USA.
ISRN Endocrinol. 2012;2012:965243. doi: 10.5402/2012/965243. Epub 2012 Jul 18.
Bisphenol A (BPA) is a widely used chemical. We examined the association between urinary BPA levels and obesity in the National Health and Nutritional Examination Survey (NHANES) 2003-2008. The main outcome of interest was obesity defined as (1) body mass index (BMI) ≥ 30 Kg/m(2) and (2) waist circumference (WC) ≥ 102 cm in men and ≥ 88 cm in women. Urinary BPA levels were examined in quartiles. Overall, we observed a positive association between increasing levels of urinary BPA and both measures of obesity, independent of potential confounding factors including, smoking, alcohol consumption, and serum cholesterol levels. Compared to quartile 1 (referent), the multivariate-adjusted odds ratio (95% confidence interval) associated with quartile 4 for BMI-based obesity was 1.69 (1.30-2.20); P-trend < 0.0001 and for WC-based obesity was 1.59 (1.21-2.09); P-trend = 0.0009. This association between BPA and both measures of obesity was consistently present across gender and race-ethnic groups (all P-trend < 0.05). Elevated levels of urinary BPA are associated with measures of obesity independent of traditional risk factors. This association is consistently present across gender and race-ethnic groups. Future prospective studies are needed to confirm or disprove this finding.
双酚A（BPA）是一种广泛使用的化学物质。我们在2003 - 2008年美国国家健康与营养检查调查（NHANES）中研究了尿中双酚A水平与肥胖之间的关联。主要关注的结果是肥胖，定义为：（1）体重指数（BMI）≥30 kg/m²；（2）男性腰围（WC）≥102 cm，女性腰围≥88 cm。尿中双酚A水平按四分位数进行检测。总体而言，我们观察到尿中双酚A水平升高与肥胖的两种测量指标之间存在正相关，且不受包括吸烟、饮酒和血清胆固醇水平等潜在混杂因素的影响。与第一四分位数（参照组）相比，基于BMI的肥胖，与第四四分位数相关的多变量调整比值比（95%置信区间）为1.69（1.30 - 2.20）；P趋势<0.0001，基于WC的肥胖为1.59（1.21 - 2.09）；P趋势 = 0.0009。双酚A与肥胖的两种测量指标之间的这种关联在不同性别和种族 - 族裔群体中均持续存在（所有P趋势<0.05）。尿中双酚A水平升高与肥胖测量指标相关，且不受传统风险因素的影响。这种关联在不同性别和种族 - 族裔群体中均持续存在。需要未来的前瞻性研究来证实或反驳这一发现。
