Bigambo Francis Manyori, Sun Jian, Zhu Chun, Zheng Songshan, Xu Yang, Wu Di, Xia Yankai, Wang Xu
Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
Department of Emergency, Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
Toxics. 2024 Jul 11;12(7):503. doi: 10.3390/toxics12070503.
There is limited evidence about the gender- and obesity-specific effects of personal care product and plasticizing chemicals (PCPPCs) on short sleep duration in adults. We evaluated the gender- and obesity-specific association of co-exposure to PCPPCs and short sleep duration among adults aged 20-60 years using the National Health and Nutrition Examination Survey (NHANES) 2011-2016, a secondary data source from the United States. Seventeen PCPPCs, including five phenols, two parabens, and ten phthalates, were detected, and sleep duration was assessed among 3012 adults. Logistic regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) were employed. We found that bisphenol A (BPA), mono (caboxy-isooctyl) phthalate (MCOP), and mono (3-carboxypropyl) phthalate (MCPP) were consistently positively associated with short sleep duration in both females and males regardless of obesity status, except for BPA with general obesity. In particular, mono benzyl phthalate (MBzP) revealed a positive association in females, mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) revealed a positive association in males, and MiBP revealed a positive association in abdominal obesity. Similar associations were observed in the mixture. Our study highlights that PCPPCs are independently associated with an increasing risk of short sleep duration in adults both individually and as a mixture; however, gender- and obesity-specific differences may have little effect on certain individual PCPPCs on short sleep duration.
关于个人护理产品和增塑化学品（PCPPCs）对成年人短睡眠时间的性别和肥胖特异性影响的证据有限。我们利用2011 - 2016年美国国家健康与营养检查调查（NHANES）这一二手数据源，评估了20至60岁成年人中PCPPCs共同暴露与短睡眠时间之间的性别和肥胖特异性关联。检测到17种PCPPCs，包括5种酚类、2种对羟基苯甲酸酯类和10种邻苯二甲酸酯类，并对3012名成年人的睡眠时间进行了评估。采用了逻辑回归、加权分位数和（WQS）回归以及贝叶斯核机器回归（BKMR）。我们发现，双酚A（BPA）、单（羧基异辛基）邻苯二甲酸酯（MCOP）和单（3 - 羧基丙基）邻苯二甲酸酯（MCPP）无论肥胖状况如何，在女性和男性中均与短睡眠时间始终呈正相关，但BPA与一般肥胖情况除外。特别是，邻苯二甲酸单苄酯（MBzP）在女性中显示出正相关，单（2 - 乙基 - 5 - 氧代己基）邻苯二甲酸酯（MEOHP）在男性中显示出正相关，间苯二甲酸二异丁酯（MiBP）在腹型肥胖中显示出正相关。在混合物中也观察到了类似的关联。我们的研究强调，PCPPCs无论是单独还是作为混合物，都与成年人短睡眠时间风险增加独立相关；然而，性别和肥胖特异性差异可能对某些个体PCPPCs对短睡眠时间的影响不大。
