Zhang Haijun
Department of Oncology, Zhongda Hospital, Southeast University, Nanjing 210009, China.
J Nanosci Nanotechnol. 2012 May;12(5):4012-8. doi: 10.1166/jnn.2012.6160.
Biocompatible nanomaterials have emerged as ideal platforms to develop multi-functionalization for achieving a compound effect using one system in which each component has a specially designed function. In this context, this article reviews multifunctional nanomedicine platforms for cancer therapy. The paper describes different types of multifunctional nanomedicine platforms, mainly co-delivery of drugs/genes in a single formulation for synergistic anticancer effect, specific strategies for targeting cancer therapy, smart control released drug delivery systems responding to certain internal or external stimuli, paradigms for theranostics to monitor effects in real time, and combination drug with thermal, sound, and light energies mediating multi-mode cancer treatment. Multifunctional nanomedicine platforms with different designs and therapeutic approaches for cancer and their translation from bench to bedside offer promising opportunities to benefit patients in the future.
生物相容性纳米材料已成为理想的平台，可用于开发多功能化，以便在一个系统中实现复合效应，其中每个组件都具有专门设计的功能。在此背景下，本文综述了用于癌症治疗的多功能纳米医学平台。该论文描述了不同类型的多功能纳米医学平台，主要包括在单一制剂中共同递送药物/基因以产生协同抗癌效果、靶向癌症治疗的特定策略、响应某些内部或外部刺激的智能控释药物递送系统、实时监测效果的诊疗一体化范例，以及结合热、声和光能介导多模式癌症治疗的联合药物。具有不同癌症设计和治疗方法的多功能纳米医学平台及其从实验室到临床的转化为未来使患者受益提供了有希望的机会。
