Department of Endocrinology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.
Biomed Pharmacother. 2024 Jul;176:116840. doi: 10.1016/j.biopha.2024.116840. Epub 2024 May 30.
Thyroid cancer, the most prevalent cancer of the endocrine system and cervical region, has experienced a significant increase in incidence over recent decades. Nanomedicine has fundamentally revolutionized cancer treatment, particularly through the development of multifunctional nano-therapeutics. The progress in this field has been facilitated by the distinctive properties of nanomaterials, such as their capacity to perform several functions, be modified, and offer various detection methods. These features allow for non-invasive and practical diagnostic techniques through versatile imaging. Surface engineering plays a pivotal role in the design of multifunctional nano-systems for localized drug delivery against thyroid cancer. Nano-systems can be customized via surface modification techniques, such as functionalization with targeting ligands and inclusion of therapeutic drugs. This customization allows the nano-systems to specifically target cancer cells while reducing the impact on non-target cells. As a result, bovine serum albumin-coated nanostructures have emerged as powerful diagnostic and targeting nanosystems for thyroid cancer. This targeted strategy enhances the effectiveness of cancer treatment while reducing overall body toxicity. This comprehensive review aims to provide an extensive overview of the latest advancements in surface-engineered nanoparticle-based approaches for both diagnosing and treating thyroid cancer. It highlights the promising research endeavors aimed at creating novel and effective multifunctional nanomedicine for localized delivery to thyroid cancer sites. The review examines different nanomedicines that have been developed for cancer treatment and diagnosis. It also analyzes the current trends, future possibilities, and obstacles in this rapidly advancing sector. By synthesizing the current state of knowledge on surface-engineered multifunctional nano-systems, this review contributes to a better understanding of their potential applications in thyroid cancer treatment and paves the way for future research directions in this promising field of nanomedicine.
甲状腺癌是内分泌系统和颈部最常见的癌症，近年来发病率显著上升。纳米医学从根本上改变了癌症治疗方法，特别是通过开发多功能纳米治疗药物。纳米材料的独特性质促进了这一领域的进展，例如它们具有执行多种功能、可修饰和提供各种检测方法的能力。这些特性允许通过多功能成像进行非侵入性和实用的诊断技术。表面工程在设计针对甲状腺癌的局部药物递送的多功能纳米系统中起着关键作用。纳米系统可以通过表面修饰技术进行定制，例如用靶向配体功能化和包含治疗药物。这种定制使纳米系统能够特异性地靶向癌细胞，同时减少对非靶细胞的影响。因此，牛血清白蛋白包覆的纳米结构已成为用于甲状腺癌的强大诊断和靶向纳米系统。这种靶向策略提高了癌症治疗的效果，同时降低了全身毒性。本综述旨在广泛概述用于甲状腺癌诊断和治疗的表面工程纳米粒子方法的最新进展。它强调了旨在为甲状腺癌部位的局部递送创造新型有效多功能纳米医学的有前途的研究努力。该综述检查了为癌症治疗和诊断开发的不同纳米医学。它还分析了这个快速发展领域的当前趋势、未来可能性和障碍。通过综合表面工程多功能纳米系统的当前知识状态，本综述有助于更好地理解它们在甲状腺癌治疗中的潜在应用，并为这个有前途的纳米医学领域的未来研究方向铺平了道路。
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