阴离子型聚氨酯纳米颗粒的制备及其血液相容性研究
Preparation of anionic polyurethane nanoparticles and blood compatible behaviors.
作者信息
Zhu Qinshu, Wang Yan, Zhou Min, Mao Chun, Huang Xiaohua, Bao Jianchun, Shen Jian
机构信息
Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China.
出版信息
J Nanosci Nanotechnol. 2012 May;12(5):4051-6. doi: 10.1166/jnn.2012.5858.
The anionic polyurethane nanoparticles (APU-NPs) were obtained by an emulsion polymerization method. It was found that the average size of the prepared APU-NPs is about 84 nm, and the APU-NPs have zeta-potential of -38.9 mV. The bulk characterization of synthesized APU-NPs was investigated by FTIR. The blood compatibility of APU-NPs was characterized by in vitro for coagulation tests, complement activation, platelet activation, cytotoxicity experiments, and hemolysis assay. The results showed that the APU-NPs synthesized in this paper are blood compatible with low level of cell cytotoxicity, and the results were significant for their potential use in vivo.
通过乳液聚合法制备了阴离子型聚氨酯纳米颗粒（APU-NPs）。发现所制备的APU-NPs的平均尺寸约为84nm，且其ζ电位为-38.9mV。通过傅里叶变换红外光谱（FTIR）对合成的APU-NPs进行了整体表征。通过体外凝血试验、补体激活、血小板激活、细胞毒性实验和溶血试验对APU-NPs的血液相容性进行了表征。结果表明，本文合成的APU-NPs具有血液相容性，细胞毒性水平较低，这些结果对于它们在体内的潜在应用具有重要意义。
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