Han Qiaorong, Chen Xiaohan, Wang Weijuan, Zhao Wenbo, Wang Kuai, Wang Bingxiang, Shen Jian
J Nanosci Nanotechnol. 2015 Jan;15(1):138-43. doi: 10.1166/jnn.2015.8770.
Biosafety assessment of nanoparticles has been of great interest in the development of nanoscience and nanotechnology. Here, the water-soluble hyperbranched polyester nanoparticles with carboxylic acid functional group (HBPE-CA NPs) are synthesized and characterized. They have amphiphilic structure that include hydrophobic hyperbranched polyester (HBPE) core and hydrophilic carboxylated terminal groups. Biosafety assessment tests of the HBPE-CA NPs include coagulation times, hemolysis, complement activation, platelet activation and cytotoxicity (MTT) are performed. The results show that the HBPE-CA NPs exhibit good hemocompatibility that strongly depend on the amphiphilic structure. Moreover, the results also indicate the non-cytotoxicity of the HBPE-CA NPs. So the HBPE-CA NPs provide a promising platform of blood circulation system for illness therapy with the help of the drug-loaded capacity of-HBPE.
纳米颗粒的生物安全性评估在纳米科学和纳米技术的发展中备受关注。在此，合成并表征了具有羧酸官能团的水溶性超支化聚酯纳米颗粒（HBPE-CA NPs）。它们具有两亲结构，包括疏水的超支化聚酯（HBPE）核心和亲水的羧基末端基团。对HBPE-CA NPs进行了生物安全性评估测试，包括凝血时间、溶血、补体激活、血小板激活和细胞毒性（MTT）。结果表明，HBPE-CA NPs表现出良好的血液相容性，这强烈依赖于其两亲结构。此外，结果还表明HBPE-CA NPs无细胞毒性。因此，借助HBPE的载药能力，HBPE-CA NPs为疾病治疗提供了一个有前景的血液循环系统平台。
