Kusumoto H, Maehara Y, Sakaguchi Y, Kohnoe S, Kumashiro R, Sugimachi K
Cancer Center, Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Anticancer Res. 1990 Nov-Dec;10(6):1643-5.
Exponentially growing HeLa cells were treated with various antitumor drugs and dipyridamole (DP), and the cell growth inhibition ratio was determined. Enhanced growth inhibition was found in combined treatment with DP and 5-fluorouracil, 1-hexylcarbamoyl-5-fluorouracil, methotrexate, adriamycin, daunomycin, 4'-0-tetrahydropyranyl-adriamycin, actinomycin D and vincristine. In contrast, reduction of the cytotoxic effect of cytosine arabinoside and enocitabine was found when these were combined with DP.
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