Maehara Y, Sakaguchi Y, Kusumoto T, Kusumoto H, Sugimachi K
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Anticancer Res. 1989 Jul-Aug;9(4):967-9.
Evidence was obtained for the augmentation of cytotoxic effects of 5-fluorouracil (5-FU) when hyperthermia and dipyridamole (DP) were combined in vitro. Nontoxic levels of DP enhanced the combined cytotoxicity of 5-FU and heat against HeLa and B16 melanoma cells, and the 50% effective concentration of 5-FU decreased 7.3 fold for HeLa cells and 3.0 fold for B16 melanoma cells, when exposed to heat plus DP. This combined effect did not depend on intracellular increases in the concentrations of 5-FU. Thus hyperthermia together with DP seems to improve the sensitivity of tumor cells to 5-FU. As the sensitivity of colorectal cancer tissue to drugs is low, 5-FU plus hyperthermia and DP shows promise for the treatment of such patients.
有证据表明，在体外将热疗与双嘧达莫（DP）联合使用时，5-氟尿嘧啶（5-FU）的细胞毒性作用会增强。无毒水平的DP增强了5-FU和热对HeLa细胞和B16黑色素瘤细胞的联合细胞毒性，当暴露于热加DP时，HeLa细胞的5-FU 50%有效浓度降低了7.3倍，B16黑色素瘤细胞降低了3.0倍。这种联合效应并不依赖于细胞内5-FU浓度的增加。因此，热疗与DP联合似乎可以提高肿瘤细胞对5-FU的敏感性。由于结直肠癌组织对药物的敏感性较低，5-FU加用热疗和DP对这类患者的治疗显示出前景。
