Department of Surgery, Valdecilla Hospital, Spain.
World J Surg Oncol. 2012 Aug 1;10:156. doi: 10.1186/1477-7819-10-156.
Centrally necrotizing carcinoma is a rare subtype of breast carcinoma, which is characterized by an extensive central necrotic zone accounting for at least 70% of the cross-sectional area of the neoplasm. This central necrotic zone, in turn, is surrounded by a narrow rim of proliferative viable tumor cells. We report an unusual clinical situation in which a patient whose evident breast mass suggested an ipsilateral local recurrence and for which numerous attempts to confirm the histological diagnosis had failed. The patient was treated with a radical mastectomy based on clinical suspicion of breast cancer recurrence after an undesirable delay. In this case, the narrow rim of viable malignant tissue had a thickness of 0.5 to 8 mm, and the centrally necrotizing carcinoma had a central zone with a predominance of fibrosis. The special features of this case led to a misdiagnosis and to an evident clinical local recurrence.
中央性坏死性乳腺癌是一种罕见的乳腺癌亚型，其特征是广泛的中央坏死区，占肿瘤横截面积的至少 70%。这个中央坏死区，反过来又被一层狭窄的增生存活肿瘤细胞边缘包围。我们报告了一个不寻常的临床情况，患者明显的乳房肿块提示同侧局部复发，并且为了确认组织学诊断，已经进行了多次尝试，但均未成功。由于对乳腺癌复发的临床怀疑，该患者在经历了一段不适当的延迟后，接受了根治性乳房切除术。在这种情况下，存活的恶性组织的窄边厚度为 0.5 至 8 毫米，而中央性坏死性乳腺癌的中央区以纤维化为主。这个病例的特殊特征导致了误诊和明显的临床局部复发。
