Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Int J Urol. 2013 Feb;20(2):150-60. doi: 10.1111/j.1442-2042.2012.03101.x. Epub 2012 Jul 31.
Quite a few epidemiological studies including meta-analyses indicate that prostate inflammation is associated with increased risk of prostate cancer. The cause of inflammation in the prostate is speculated to be several microorganisms that cause prostatitis or sexually transmitted infections. Other specific microorganisms, such as xenotropic murine leukemia virus-related virus, are also reported to relate to the development of prostate cancer; however, the contribution of this microorganism to prostate cancer development needs to be carefully interpreted. Environmental factors, especially dietary factors, might also be associated with prostate cancer development. Among related dietary factors, charred meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine might be a link between environmental factors and inflammation, because 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine has the potential to accelerate prostate inflammation through its estrogenic effect. In light of these findings, preventing or reducing prostate inflammation might be one strategy for chemoprevention of prostate cancer.
相当多的流行病学研究包括荟萃分析表明，前列腺炎症与前列腺癌风险增加有关。前列腺炎症的原因据推测是几种引起前列腺炎或性传播感染的微生物。其他特定的微生物，如嗜性鼠白血病病毒相关病毒，也被报道与前列腺癌的发展有关；然而，这种微生物对前列腺癌发展的贡献需要仔细解释。环境因素，特别是饮食因素，也可能与前列腺癌的发展有关。在相关的饮食因素中，焦肉致癌剂 2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶可能是环境因素和炎症之间的联系，因为 2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶通过其雌激素效应有可能加速前列腺炎症。鉴于这些发现，预防或减少前列腺炎症可能是前列腺癌化学预防的一种策略。
