Department of Surgery, New York Hospital Medical Center Queens, New York City, New York, USA.
J Toxicol Environ Health A. 2012;75(16-17):1091-101. doi: 10.1080/15287394.2012.697840.
Methylmercury (MeHg) is a global environmental pollutant with significant adverse effects on human health. As the major target of MeHg, the central nervous system (CNS) exhibits the most recognizable poisoning symptoms. The role of the two major nonneuronal cell types, astrocytes and microglia, in response to MeHg exposure was recently compared. These two cell types share several common features in MeHg toxicity, but interestingly, these cells types also exhibit distinct response kinetics, indicating a cell-specific role in mediating MeHg-induced neurotoxicity. The aim of this study was to review the most recent literature and summarize key features of glial responses to this organometal.
甲基汞（MeHg）是一种全球性的环境污染物，对人类健康有重大的不良影响。作为 MeHg 的主要靶标，中枢神经系统（CNS）表现出最明显的中毒症状。最近比较了两种主要的非神经元细胞类型，星形胶质细胞和小胶质细胞，对 MeHg 暴露的反应。这两种细胞类型在 MeHg 毒性中有一些共同的特征，但有趣的是，这些细胞类型也表现出不同的反应动力学，表明它们在介导 MeHg 诱导的神经毒性方面具有细胞特异性作用。本研究旨在综述最近的文献，总结胶质细胞对这种有机金属的反应的关键特征。
