头孢拉定与阿莫西林-克拉维酸治疗复发性尿路感染的对比研究
Comparative study of cephradine and amoxicillin-clavulanate in the treatment of recurrent urinary tract infections.
作者信息
Brumfitt W, Hamilton-Miller J M
机构信息
Urinary Infection Clinic, Royal Free Hospital, Hampstead, London, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1990 Sep;34(9):1803-5. doi: 10.1128/AAC.34.9.1803.
Eighty-eight female patients with a history of recurrent urinary tract infections were treated according to a randomization scheme with either 1 g of cephradine every 12 h (47 patients) or 375 mg of amoxicillin-clavulanate every 8 h (41 patients) for 7 days. The treatments were equally effective (cure rates of 89% for cephradine and 88% for amoxicillin-clavulanate) and showed similar relapse rates (cephradine, 14%; amoxicillin-clavulanate, 11%). Adverse effects were similar in both groups (cephradine, 23%; amoxicillin-clavulanate, 22%).
88例有复发性尿路感染病史的女性患者，按照随机方案接受治疗，一组每12小时服用1g头孢拉定（47例患者），另一组每8小时服用375mg阿莫西林-克拉维酸（41例患者），疗程均为7天。两种治疗效果相当（头孢拉定治愈率89%，阿莫西林-克拉维酸治愈率88%），复发率也相似（头孢拉定14%，阿莫西林-克拉维酸11%）。两组的不良反应相似（头孢拉定23%，阿莫西林-克拉维酸22%）。
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