Brumfitt W, Hamilton-Miller J M
Antimicrob Agents Chemother. 1984 Feb;25(2):276-8. doi: 10.1128/AAC.25.2.276.
Forty-four patients (43 female, 1 male), all with a history of recurrent urinary tract infections, were treated with 250 mg of amoxicillin plus 125 mg of clavulanic acid (one tablet of Augmentin) every 8 h for 7 days. The microbiological cure rates were 84% 1 week after the end of treatment and 67% 1 month later. Side effects, which were reported by 20% of the patients, were mild and in no case caused interruption of treatment. In view of the increasing trend in resistance to agents commonly used for the treatment of urinary tract infections in outpatients, the combination of amoxicillin and clavulanic acid may now be considered a first-line drug in patients with recurrent urinary tract infections.
44例患者（43例女性，1例男性）均有复发性尿路感染病史，接受每8小时服用250毫克阿莫西林加125毫克克拉维酸（一片奥格门汀），共治疗7天。治疗结束1周后微生物治愈率为84%，1个月后为67%。20%的患者报告有副作用，症状轻微，无一例导致治疗中断。鉴于门诊患者对常用于治疗尿路感染的药物耐药性呈上升趋势，阿莫西林和克拉维酸联合用药现在可被视为复发性尿路感染患者的一线药物。
