Injury Research Institute, Monash University, Melbourne, Victoria 3800, Australia.
BMC Med Res Methodol. 2012 Aug 1;12:113. doi: 10.1186/1471-2288-12-113.
Studies comparing internally linked (person-identifying) and unlinked (episodes of care) hospital discharge data (HDD) on hip fractures have mainly focused on incidence overestimation by unlinked HDD, but little is known about the impact of overestimation on patient profiles such as comorbidity estimates. In view of the continuing use of unlinked HDD in hip fracture research and the desire to apply research results to hip fracture prevention, we concurrently assessed the accuracy of both incidence and comorbidity estimates derived from unlinked HDD compared to those estimated from internally linked HDD.
We analysed unlinked and internally linked HDD between 01 July 2005 and 30 June 2008, inclusive, from Victoria, Australia to estimate the incidence of hospital admission for fall-related hip fracture in community-dwelling older people aged 65+ years and determine the prevalence of comorbidity in patients. Community-dwelling status was defined as living in private residence, supported residential facilities or special accommodation but not in nursing homes. We defined internally linked HDD as the reference standard and calculated measures of accuracy of fall-related hip fracture incidence by unlinked HDD using standard definitions. The extent to which comorbidity prevalence estimates by unlinked HDD differed from those by the reference standard was assessed in absolute terms.
The sensitivity and specificity of a standard approach for estimating fall-related hip fracture incidence using unlinked HDD (i.e. omitting records of in-hospital deaths, inter-hospital transfers and readmissions within 30 days of discharge) were 94.4% and 97.5%, respectively. The standard approach and its variants underestimated the prevalence of some comorbidities and altered their ranking. The use of more stringent selection criteria led to major improvements in all measures of accuracy as well as overall and specific comorbidity estimates.
This study strongly supports the use of linked rather than unlinked HDD in injury research. In health systems where linked HDD are unavailable, current approaches for identifying incident hip fractures may be enhanced by incorporating additional evidence-based criteria.
比较内部链接(人员识别)和未链接(医疗记录)的医院出院数据(HDD)的髋部骨折研究主要集中在未链接 HDD 导致的发病率高估上,但对于发病率高估对患者特征(如合并症估计)的影响知之甚少。鉴于未链接 HDD 在髋部骨折研究中的持续使用以及将研究结果应用于髋部骨折预防的愿望,我们同时评估了从内部链接 HDD 和未链接 HDD 得出的发病率和合并症估计的准确性,以与从内部链接 HDD 得出的估计值进行比较。
我们分析了澳大利亚维多利亚州 2005 年 7 月 1 日至 2008 年 6 月 30 日期间的未链接和内部链接 HDD,以估计 65 岁以上社区居住老年人因跌倒导致的髋部骨折的住院率,并确定患者的合并症患病率。社区居住状态定义为居住在私人住宅、支持性居住设施或特殊住所,但不居住在养老院。我们将内部链接 HDD 定义为参考标准,并使用标准定义计算未链接 HDD 计算与跌倒相关的髋部骨折发病率的准确性指标。使用未链接 HDD 计算合并症患病率估计值与参考标准之间的差异程度是通过绝对值来评估的。
使用未链接 HDD 估计与跌倒相关的髋部骨折发病率的标准方法(即排除住院死亡、医院间转移和出院后 30 天内再次入院的记录)的灵敏度和特异性分别为 94.4%和 97.5%。标准方法及其变体低估了一些合并症的患病率,并改变了它们的排名。使用更严格的选择标准可显著提高所有准确性指标以及整体和特定合并症的估计值。
这项研究强烈支持在伤害研究中使用链接而非未链接的 HDD。在无法获得链接 HDD 的卫生系统中,通过纳入额外基于证据的标准,当前用于识别髋部骨折的方法可能会得到改进。