Department of Pharmacology, University of Toronto, Toronto, ON, Canada.
Expert Rev Neurother. 2012 Jul;12(7):849-59. doi: 10.1586/ern.12.64.
Bipolar disorder (BD) has been consistently associated with altered levels of oxidative stress markers, although the cause and consequences of these alterations remain to be elucidated. One of the main hypotheses regarding the pathogenesis of mania involves increased dopaminergic transmission. In this review, the authors aim to discuss a potential mechanism by which increased oxidative stress inhibits the uptake of dopamine through the post-translational modification of the dopamine transporter and its implications for BD. Within the next 5 years, the authors believe that the mechanisms of dopamine transporter oxidation and its impact on the pathophysiology of BD will be elucidated, which may open avenues for the development of more specific interventions for the treatment of this debilitating illness.
双相情感障碍（BD）与氧化应激标志物水平的改变密切相关，尽管这些改变的原因和后果仍有待阐明。关于躁狂症发病机制的主要假设之一涉及多巴胺能传递的增加。在这篇综述中，作者旨在讨论一种潜在的机制，即通过多巴胺转运体的翻译后修饰，增加氧化应激如何抑制多巴胺的摄取，并探讨其对 BD 的影响。在未来 5 年内，作者相信多巴胺转运体氧化的机制及其对 BD 病理生理学的影响将被阐明，这可能为开发更针对这种使人衰弱的疾病的治疗方法开辟途径。
