Dermatology Department.
Eur J Dermatol. 2012 Sep-Oct;22(5):622-8. doi: 10.1684/ejd.2012.1789.
Growing evidence points to a causative relationship between altered activity of peroxisome proliferator-activated receptor γ (PPARγ) and psoriasis on the one hand, and its relationship with metabolic syndrome (MS) on the other.
Could altered PPARγ levels be one of the culprits responsible for translating the metabolic state among psoriatic patients?
This investigational cross-sectional study included 60 psoriatics and 60 controls. Subjects were subgrouped according to the presence or absence of MS. Biopsies were taken from all subjects for immunohistochemical staining for PPARγ and western blot technique was carried out.
PPARγ immunostaining in psoriatics was significantly lower than in controls with the lowest levels documented in patients with MS (P<0.001). PPARγ immunostaining level was significantly lower in diabetics, hypertensive and insulin resistance patients (P<0.05). It also showed a significant positive correlation with high density lipoprotein (HDL) levels and significant negative correlation with age, psoriasis area and severity index (PASI), body mass index, and blood glucose levels. Similar results were obtained by western blot technique.
Reduced PPARγ could be added to the factors responsible for translating the metabolic state among psoriatic patients. PPARγ agonists can present an adjuvant therapeutic tool in treatment of psoriatics with MS.
越来越多的证据表明，过氧化物酶体增殖物激活受体 γ (PPARγ) 的活性改变与银屑病一方面，以及与代谢综合征 (MS) 的关系。
PPARγ 水平的改变是否是导致银屑病患者代谢状态改变的原因之一？
本研究为横断面研究，共纳入 60 例银屑病患者和 60 例对照。根据是否存在 MS 将患者分为亚组。对所有患者进行免疫组化染色检测 PPARγ，并进行 Western blot 技术检测。
银屑病患者的 PPARγ 免疫染色明显低于对照组，MS 患者的水平最低（P<0.001）。糖尿病、高血压和胰岛素抵抗患者的 PPARγ 免疫染色水平较低（P<0.05）。它还与高密度脂蛋白 (HDL) 水平呈显著正相关，与年龄、银屑病面积和严重程度指数 (PASI)、体重指数和血糖水平呈显著负相关。Western blot 技术也得到了类似的结果。
PPARγ 的减少可能是导致银屑病患者代谢状态改变的因素之一。PPARγ 激动剂可作为治疗合并 MS 的银屑病患者的辅助治疗手段。
