Seleit Iman, Bakry Ola Ahmed, Abd El Gayed Eman, Ghanem Mai
Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Shibeen El Koom, Egypt.
Department of Medical Biochemistry, Faculty of Medicine, Menoufiya University, Shibeen El Koom, Egypt.
Indian J Dermatol. 2019 May-Jun;64(3):192-200. doi: 10.4103/ijd.IJD_114_18.
Psoriasis is a common dermatologic disease with multifactorial etiology in which genetic factors play a major role. Peroxisome proliferator-activated receptor (PPAR)-γ is expressed in keratinocytes and is known to affect cell maturation and differentiation in addition to its role in inflammation.
To study the association between PPAR-γ gene polymorphism and psoriasis vulgaris in Egyptian patients to explore if this polymorphism influenced disease risk or clinical presentation.
Forty-five patients with psoriasis vulgaris and 45 age, sex and body mass index matched healthy volunteers who have no present, past or family history of psoriasis as a control group were enrolled. Selected cases included obese and nonobese participants. Detection of PPAR-γ gene polymorphism was done with restriction fragment length polymorphism polymerase chain reaction. Narrow-band ultraviolet B (NBUVB) was given for every case three times/week for 12 weeks.
Homopolymorphism, heteropolymorphism, and Ala allele were significantly associated with cases ( = 0.01, = 0.01, and = 0.004, respectively) and increased risk of occurrence of psoriasis by 5.25, 3.65, and 3.37 folds, respectively. Heteropolymorphism was significantly associated with nonobese cases compared to obese ones ( = 0.01). Ala allele was significantly associated with obese cases ( = 0.001) and increased risk of occurrence of psoriasis in obese participants by 1.14 folds. Homopolymorphism, heteropolymorphism, and Ala allele were more prevalent among obese cases without metabolic syndrome (MS) than obese cases with MS but without statistical significance. Percentage of decrease of mean Psoriasis Area and Severity Index score before and after 3 months of treatment with NBUVB was higher in cases with heteropolymorphism with no significant difference between homo- and heteropolymorphism.
PPAR-γ gene polymorphism is associated with and increased the risk of psoriasis and its associated obesity in Egyptian patients. It has no role in NBUVB response in those patients. Future large-scale studies on different populations are recommended.
银屑病是一种病因多因素的常见皮肤病，其中遗传因素起主要作用。过氧化物酶体增殖物激活受体（PPAR）-γ在角质形成细胞中表达，除了在炎症中的作用外，还已知其影响细胞成熟和分化。
研究埃及患者中PPAR-γ基因多态性与寻常型银屑病之间的关联，以探讨这种多态性是否影响疾病风险或临床表现。
纳入45例寻常型银屑病患者和45例年龄、性别和体重指数相匹配的健康志愿者作为对照组，这些志愿者无银屑病的现患、既往或家族史。所选病例包括肥胖和非肥胖参与者。采用限制性片段长度多态性聚合酶链反应检测PPAR-γ基因多态性。对每个病例每周进行3次窄谱中波紫外线（NBUVB）照射，共12周。
纯合多态性、杂合多态性和丙氨酸等位基因与病例显著相关（分别为P = 0.01、P = 0.01和P = 0.004），银屑病发生风险分别增加5.25倍、3.65倍和3.37倍。与肥胖病例相比，杂合多态性与非肥胖病例显著相关（P = 0.01）。丙氨酸等位基因与肥胖病例显著相关（P = 0.001），肥胖参与者中银屑病发生风险增加1.14倍。纯合多态性、杂合多态性和丙氨酸等位基因在无代谢综合征（MS）的肥胖病例中比有MS的肥胖病例更常见，但无统计学意义。NBUVB治疗3个月前后，杂合多态性病例的银屑病面积和严重程度指数平均得分下降百分比更高，纯合和杂合多态性之间无显著差异。
PPAR-γ基因多态性与埃及患者银屑病及其相关肥胖有关，并增加了其风险。它对这些患者的NBUVB反应无影响。建议未来对不同人群进行大规模研究。
