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Where vaptans do and do not fit in the treatment of hyponatremia.缬沙坦在治疗低钠血症中的作用和不适用情况。
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引用本文的文献

1
SIADH and partial hypopituitarism in a patient with intravascular large B-cell lymphoma: a rare cause of a common presentation.血管内大B细胞淋巴瘤患者出现抗利尿激素分泌异常综合征和部分垂体功能减退:一种常见临床表现的罕见病因。
BMJ Case Rep. 2013 Jan 28;2013:bcr2012007147. doi: 10.1136/bcr-2012-007147.

本文引用的文献

1
Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder.抗利尿激素分泌不当综合征:重温一种经典的内分泌疾病。
Indian J Endocrinol Metab. 2011 Sep;15 Suppl 3(Suppl3):S208-15. doi: 10.4103/2230-8210.84870.
2
Utility and limitations of the traditional diagnostic approach to hyponatremia: a diagnostic study.低钠血症传统诊断方法的实用性和局限性:一项诊断研究。
Am J Med. 2010 Jul;123(7):652-7. doi: 10.1016/j.amjmed.2010.01.013.
3
SIADH and hyponatraemia: why does it matter?抗利尿激素分泌失调综合征与低钠血症:为何重要?
NDT Plus. 2009 Nov;2(Suppl_3):iii5-iii11. doi: 10.1093/ndtplus/sfp153.
4
The treatment of hyponatremia.低钠血症的治疗。
Semin Nephrol. 2009 May;29(3):282-99. doi: 10.1016/j.semnephrol.2009.03.002.
5
Clinical practice. The syndrome of inappropriate antidiuresis.临床实践。抗利尿激素分泌失调综合征
N Engl J Med. 2007 May 17;356(20):2064-72. doi: 10.1056/NEJMcp066837.
6
Severe hyponatraemia in medical in-patients: aetiology, assessment and outcome.住院内科患者的严重低钠血症:病因、评估与转归
QJM. 2006 Aug;99(8):505-11. doi: 10.1093/qjmed/hcl071. Epub 2006 Jul 22.
7
Vasopressin antagonists.血管加压素拮抗剂
Cell Mol Life Sci. 2006 Aug;63(15):1766-79. doi: 10.1007/s00018-006-6054-2.
8
Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats.锂在治疗抗利尿激素分泌异常综合征(SIADH)大鼠低钠血症方面可有效补充血管加压素V2受体拮抗剂的作用。
Nephrol Dial Transplant. 2007 Jan;22(1):68-76. doi: 10.1093/ndt/gfl110. Epub 2006 May 15.
9
Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial.血管加压素拮抗剂托伐普坦对心力衰竭加重住院患者的影响:一项随机对照试验。
JAMA. 2004 Apr 28;291(16):1963-71. doi: 10.1001/jama.291.16.1963.
10
Rapid correction of hyponatremia causes demyelination: relation to central pontine myelinolysis.低钠血症的快速纠正会导致脱髓鞘:与中央脑桥髓鞘溶解症的关系。
Science. 1981 Mar 6;211(4486):1068-70. doi: 10.1126/science.7466381.

低钠血症的罕见病例。

Unusual case of hyponatraemia.

作者信息

Hannaway Ryan Karlus, Cowie Fiona, Jude Edward

机构信息

Department of Diabetes and Endocrinology, Tameside Hospital NHS Foundation Trust, Ashton-Under-Lyne, Lancashire, UK.

出版信息

BMJ Case Rep. 2012 Aug 1;2012:bcr0320126143. doi: 10.1136/bcr-03-2012-6143.

DOI:10.1136/bcr-03-2012-6143
PMID:22854232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3624489/
Abstract

Hyponatraemia is the most common electrolyte abnormality, encountered in up to 30% of inpatients. Inappropriate management can have serious implications for patients; including demyelinating disease, coma and death. We have used a case report to identify the common problems, and provide useful strategies in management for which these can be avoided. The aim was to provide a framework which clinicians can adopt, in order to improve clinical practice and provide optimum outcome for the patient.

摘要

低钠血症是最常见的电解质异常,在高达30%的住院患者中出现。管理不当会给患者带来严重影响,包括脱髓鞘疾病、昏迷和死亡。我们通过一份病例报告来识别常见问题,并提供可避免这些问题的有用管理策略。目的是提供一个临床医生可以采用的框架,以改善临床实践并为患者提供最佳结果。