Uhm Dong Choon, Nam Eun Sook, Lee Ho Yeon, Lee Eun Bong, Yoon Young Im, Chai Gong Ju
Department of Emergency Medical Technician, Daejeon University, Daejeon, South Korea.
J Korean Acad Nurs. 2012 Jun;42(3):434-42. doi: 10.4040/jkan.2012.42.3.434.
The purpose of this predictive study was to identify factors affecting health related quality of life (HRQoL) in patients with rheumatoid arthritis (RA).
The participants in this study were 131 patients with RA who were recruited from the outpatient clinic of a university hospital in Seoul. Disease activity in rheumatoid arthritis was evaluated by calculating the Disease Activity Score 28. Disability in activities of daily living (ADL) was assessed with the Korean Health Assessment Questionnaire, and depression with The Center for Epidemiologic Studies Depression Scale. HRQoL was evaluated using The Short Form 36 Health Survey. Data were analyzed using descriptive statistics, correlation, and hierarchical multiple regression.
Pain, disability in ADL, disease activity, and depression correlated negatively with physical and mental dimensions of HRQoL. But hierachical multiple regression analysis revealed that disability in ADL and depression were the only variables negatively influencing physical and mental QoL after adjustment for influences of sociodemographic variables.
Results of this study suggest that disability in ADL and depression, rather than disease activity and pain have profound effects on HRQoL in patients with RA. Further studies are needed to assess the predictive ability of disease activity and pain on HRQoL in this population.
本预测性研究旨在确定影响类风湿关节炎（RA）患者健康相关生活质量（HRQoL）的因素。
本研究的参与者为131例RA患者，他们来自首尔一家大学医院的门诊。通过计算疾病活动评分28来评估类风湿关节炎的疾病活动度。使用韩国健康评估问卷评估日常生活活动（ADL）中的残疾情况，使用流行病学研究中心抑郁量表评估抑郁情况。使用简短健康调查问卷36评估HRQoL。采用描述性统计、相关性分析和分层多元回归分析数据。
疼痛、ADL残疾、疾病活动度和抑郁与HRQoL的身体和心理维度呈负相关。但分层多元回归分析显示，在调整社会人口学变量的影响后，ADL残疾和抑郁是仅有的对身体和心理生活质量有负面影响的变量。
本研究结果表明，ADL残疾和抑郁而非疾病活动度和疼痛对RA患者的HRQoL有深远影响。需要进一步研究评估疾病活动度和疼痛对该人群HRQoL的预测能力。
