Sambamoorthi Usha, Shah Drishti, Zhao Xiaohui
a Department of Pharmaceutical Systems and Policy , School of Pharmacy, West Virginia University , Morgantown , WV , USA.
Expert Rev Pharmacoecon Outcomes Res. 2017 Feb;17(1):53-65. doi: 10.1080/14737167.2017.1281744. Epub 2017 Jan 20.
Arthritis and depression are two of the top disabling conditions. When arthritis and depression exist in the same individual, they can interact with each other negatively and pose a significant healthcare burden on the patients, their families, payers, healthcare systems, and society as a whole. Areas covered: The primary objective of this review is to summarize, identify knowledge gaps and discuss the challenges in estimating the healthcare burden of depression among individuals with arthritis. Electronic literature searches were performed on PubMed, Embase, EBSCOhost, Scopus, the Cochrane Library, and Google Scholar to identify relevant studies. Expert Commentary: Our review revealed that the prevalence of depression varied depending on the definition of depression, type of arthritis, tools and threshold points used to identify depression, and the country of residence. Depression exacerbated arthritis-related complications as well as pain and was associated with poor health-related quality of life, disability, mortality, and high financial burden. There were significant knowledge gaps in estimates of incident depression rates, depression attributable disability, and healthcare utilization, direct and indirect healthcare costs among individuals with arthritis.
关节炎和抑郁症是导致残疾的两大主要病症。当关节炎和抑郁症同时出现在同一个人身上时，它们会相互产生负面影响，给患者本人、其家庭、医保支付方、医疗系统乃至整个社会带来沉重的医疗负担。涵盖领域：本综述的主要目的是总结、找出知识空白并讨论在评估关节炎患者中抑郁症的医疗负担时所面临的挑战。我们在PubMed、Embase、EBSCOhost、Scopus、Cochrane图书馆和谷歌学术上进行了电子文献检索，以确定相关研究。专家评论：我们的综述表明，抑郁症的患病率因抑郁症的定义、关节炎类型、用于识别抑郁症的工具和阈值点以及居住国家的不同而有所差异。抑郁症会加重与关节炎相关的并发症以及疼痛，并与健康相关生活质量差、残疾、死亡率和高昂的经济负担相关。在关节炎患者的新发抑郁症发病率、抑郁症所致残疾、医疗服务利用情况、直接和间接医疗费用的估计方面存在重大知识空白。
